Eukaryotic core promoters and the functional basis of transcription initiation
Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …
transcription start sites of protein-coding and non-coding genes that support the assembly of …
RNA sequencing: advances, challenges and opportunities
F Ozsolak, PM Milos - Nature reviews genetics, 2011 - nature.com
In the few years since its initial application, massively parallel cDNA sequencing, or RNA-
seq, has allowed many advances in the characterization and quantification of …
seq, has allowed many advances in the characterization and quantification of …
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
Abstract N 6-methyladenosine (m6A) is the most abundant modified base in eukaryotic
mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches …
mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches …
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites
Summary N6-methyladenosine (m6A) is a common modification of mRNA with potential
roles in fine-tuning the RNA life cycle. Here, we identify a dense network of proteins …
roles in fine-tuning the RNA life cycle. Here, we identify a dense network of proteins …
[PDF][PDF] Landscape and regulation of m6A and m6Am methylome across human and mouse tissues
Summary N 6-methyladenosine (m 6 A), the most abundant internal mRNA modification, and
N 6, 2′-O-dimethyladenosine (m 6 Am), found at the first-transcribed nucleotide, are two …
N 6, 2′-O-dimethyladenosine (m 6 Am), found at the first-transcribed nucleotide, are two …
The functional role of long non-coding RNA in human carcinomas
Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …
Metazoan promoters: emerging characteristics and insights into transcriptional regulation
Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …
elements, sequence motifs, the choice of transcription start sites and other features. Several …
[HTML][HTML] Analysis of transcriptome and epitranscriptome in plants using PacBio Iso-Seq and nanopore-based direct RNA sequencing
L Zhao, H Zhang, MV Kohnen, KVSK Prasad… - Frontiers in …, 2019 - frontiersin.org
Nanopore sequencing from Oxford Nanopore Technologies (ONT) and Pacific BioSciences
(PacBio) single-molecule real-time (SMRT) long-read isoform sequencing (Iso-Seq) are …
(PacBio) single-molecule real-time (SMRT) long-read isoform sequencing (Iso-Seq) are …
The core promoter: At the heart of gene expression
YM Danino, D Even, D Ideses… - Biochimica et Biophysica …, 2015 - Elsevier
The identities of different cells and tissues in multicellular organisms are determined by
tightly controlled transcriptional programs that enable accurate gene expression. The …
tightly controlled transcriptional programs that enable accurate gene expression. The …
Whole transcriptome analysis with sequencing: methods, challenges and potential solutions
Whole transcriptome analysis plays an essential role in deciphering genome structure and
function, identifying genetic networks underlying cellular, physiological, biochemical and …
function, identifying genetic networks underlying cellular, physiological, biochemical and …