Mechanisms of vertebrate DNA interstrand cross-link repair
DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …
[HTML][HTML] The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment
H Zhang, L Fu - Acta Pharmaceutica Sinica B, 2021 - Elsevier
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …
Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans
Reactive aldehydes arise as by-products of metabolism and are normally cleared by
multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes …
multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes …
The chromatin response to double-strand DNA breaks and their repair
Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
[HTML][HTML] RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
S Zhao, J Cordes, KM Caban, MJ Götz… - Molecular cell, 2023 - cell.com
Reactive aldehydes are abundant endogenous metabolites that challenge homeostasis by
crosslinking cellular macromolecules. Aldehyde-induced DNA damage requires repair to …
crosslinking cellular macromolecules. Aldehyde-induced DNA damage requires repair to …
Genotoxic aldehydes in the hematopoietic system
M Wang, FA Dingler, KJ Patel - Blood, The Journal of the …, 2022 - ashpublications.org
Reactive aldehydes are potent genotoxins that threaten the integrity of hematopoietic stem
cells and blood production. To protect against aldehydes, mammals have evolved a family of …
cells and blood production. To protect against aldehydes, mammals have evolved a family of …
K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution
AS Rahmanto, CJ Blum, C Scalera, JB Heidelberger… - Molecular Cell, 2023 - cell.com
Reactive aldehydes are produced by normal cellular metabolism or after alcohol
consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are …
consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are …
A new frontier in Fanconi anemia: From DNA repair to ribosome biogenesis
A Gueiderikh, F Maczkowiak-Chartois, F Rosselli - Blood reviews, 2022 - Elsevier
Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …
FANCM regulates repair pathway choice at stalled replication forks
Repair pathway" choice" at stalled mammalian replication forks is an important determinant
of genome stability; however, the underlying mechanisms are poorly understood. FANCM …
of genome stability; however, the underlying mechanisms are poorly understood. FANCM …
Mechanisms of damage tolerance and repair during DNA replication
ME Ashour, N Mosammaparast - Nucleic acids research, 2021 - academic.oup.com
Accurate duplication of chromosomal DNA is essential for the transmission of genetic
information. The DNA replication fork encounters template lesions, physical barriers …
information. The DNA replication fork encounters template lesions, physical barriers …