Organophosphonic acids are unique as natural products in terms of stability and mimicry.
The C–P bond that defines these compounds resists hydrolytic cleavage, while the …

Metalloaminopeptidases remove the N-terminal amino acid from proteins or small
oligopeptides. This modification or truncation process can occur either co-translationally or …

Amino phosphonates exhibit potent inhibitory activity for a wide range of biological
processes due to their specific structural and electronic properties, making them important in …

1. Introduction a-Aminoalkylphosphonic acids 1 are structurally analogous to a-amino acids
2, obtained by isosteric substitution of the planar and less bulky carboxylic acid (CO2H) by a …

We report the parametrization of the approximate density functional theory, DFTB3, for
magnesium and zinc for chemical and biological applications. The parametrization strategy …

In living organisms it is necessary to be able to perform countless hydrolysis reactions
efficiently and, above all, selectively to sustain thousands, maybe even millions, of critical …

In the past decades, shellfish culture has developed in a significant way around the world.
However, culture areas are often subject to recurring anthropic pollution. The recrudescent …

Organophosphorus compounds hold significant importance in the fields of materials
science, medicinal chemistry, pesticides and organic synthesis. In particular, phosphonate …

Parameters for the zinc ion have been developed in the self‐consistent charge density
functional tight‐binding (SCC‐DFTB) framework. The approach was tested against B3LYP …

The three-dimensional structure of the N-acyl-l-homoserine lactone hydrolase (AHL
lactonase) from Bacillus thuringiensis has been determined, by using single-wavelength …