Propofol is an intravenous hypnotic drug that is used for induction and maintenance of
sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory …

Propofol is an intravenous agent used commonly for the induction and maintenance of
anesthesia, procedural, and critical care sedation in children. The mechanisms of action on …

Synopsis Propofol is an intravenous sedative hypnotic agent which rapidly and reliably
causes loss of consciousness. It is also associated with a quick and 'smooth'recovery, which …

Propofol (2, 6‐diisopropylphenol) is a versatile, short‐acting, intravenous (iv) sedative‐
hypnotic agent initially marketed as an anesthetic, and now also widely used for the …

Propofol, a short-acting intravenous anaesthetic agent has gained wide acceptance since its
introduction in the late 80s, not only in operating rooms but also in other departments, due to …

Synopsis Propofol is a phenolic derivative that is structurally unrelated to other sedative
hypnotic agents. It has been used extensively as an anaesthetic agent, particularly in …

Background Propofol and alfentanil are frequently combined to provide general anesthesia.
The purpose of this study was to characterize the pharmacodynamic interaction between …

Background Although remifentanil provides profound analgesia during operation,
postoperative occurrence of hyperalgesia and tolerance after remifentanil administration …

BACKGROUND: Experimental and clinical studies suggest that brief opioid exposure can
enhance pain sensitivity. During anesthesia, however, opioids are commonly administered …

The pharmacokinetics and pharmacodynamics of sedatives and analgesics are significantly
altered in the critically ill. These changes may account for the large differences in drug …