Neurodegenerative diseases are characterized by the presence of cross-β-sheet amyloid
fibrils and a rich mesoscopic polymorphism, requiring noninvasive detection with high …

Nanopore sensing is nearly synonymous with resistive pulse sensing due to the
characteristic occlusion of ions during pore occupancy, particularly at high salt …

Glass nanopipets have been demonstrated to be a powerful tool for the sensing and
discrimination of biomolecules, such as DNA strands with different lengths or configurations …

Nucleic acid analysis plays an important role in disease diagnosis and treatment. The
discovery of CRISPR technology has provided novel and versatile approaches to the …

Nanopipette as a member of solid-state nanopores has been developed to detect a set of
biological molecules. Although the size of the nanopipette can be adjusted artificially, the …

The detection and identification of nanoscale molecules are crucial, but traditional
technology comes with a high cost and requires skilled operators. Solid-state nanopores are …

Solid-state nanopores have been developed as a prominent tool for single molecule
analysis in versatile applications. Although controlled dielectric breakdown (CDB) is the …

We present a new concept for the separation of DNA molecules by contour length that
combines a nanofluidic ratchet, nanopore translocation, and pulsed fields. Using Langevin …

Nowadays, research on single-stranded DNA (ssDNA) requires a quick, effective and easy
operation method to separate small ssDNA fragments from the organism and ssDNA …

Single-molecule studies on proteins could reveal a lot of information about their
conformational dynamics, and processes such as misfolding and aggregation. This …