Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
[HTML][HTML] Comparative analysis of aducanumab, zagotenemab and pioglitazone as targeted treatment strategies for Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia that has remained a major
medical, sociocultural and economical challenge globally. Previously developed treatments …
medical, sociocultural and economical challenge globally. Previously developed treatments …
Abnormal expression of mitochondrial ribosomal proteins and their encoding genes with cell apoptosis and diseases
G Huang, H Li, H Zhang - International journal of molecular sciences, 2020 - mdpi.com
Mammalian mitochondrial ribosomes translate 13 proteins encoded by mitochondrial genes,
all of which play roles in the mitochondrial respiratory chain. After a long period of …
all of which play roles in the mitochondrial respiratory chain. After a long period of …
Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer's disease
Q Cao, S Yang, X Wang, H Sun, W Chen… - Journal of Experimental …, 2024 - rupress.org
Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer’s disease |
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …
[HTML][HTML] Cell cycle deficits in neurodegenerative disorders: uncovering molecular mechanisms to drive innovative therapeutic development
Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative
disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell …
disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell …
Role of retinal amyloid-β in neurodegenerative diseases: overlapping mechanisms and emerging clinical applications
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …
Mitochondrial dysfunction in Alzheimer's disease-a proteomics perspective
M Abyadeh, V Gupta, N Chitranshi… - Expert review of …, 2021 - Taylor & Francis
Mitochondrial dysfunction is involved in Alzheimer's disease (AD) pathogenesis.
Mitochondria have their own genetic material; however, most of their proteins (∼ 99%) are …
Mitochondria have their own genetic material; however, most of their proteins (∼ 99%) are …
Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer
Z Zhou, B Sun, S Huang, D Yu, X Zhang - Cell Death & Disease, 2020 - nature.com
Aminoacyl-tRNA synthetases (ARSs) are an important class of enzymes with an
evolutionarily conserved mechanism for protein synthesis. In higher eukaryotic systems …
evolutionarily conserved mechanism for protein synthesis. In higher eukaryotic systems …
Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer's and Parkinson's disease
MI Móvio, TH de Lima-Vasconcellos… - Seminars in Cell & …, 2023 - Elsevier
Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study
neurodegenerative diseases. In addition to their wide application in neuronal disorders …
neurodegenerative diseases. In addition to their wide application in neuronal disorders …
Fingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy, and neuroinflammatory networks
Fingolimod (FTY720) is an oral drug approved by the Food and Drug Administration (FDA)
for management of multiple sclerosis (MS) symptoms, which has also shown beneficial …
for management of multiple sclerosis (MS) symptoms, which has also shown beneficial …