The role of ABC transporters in ovarian cancer progression and chemoresistance
Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …
course of the disease. A well-established cause of chemoresistance involves the family of …
Computational approaches in cancer multidrug resistance research: Identification of potential biomarkers, drug targets and drug-target interactions
Like physics in the 19th century, biology and molecular biology in particular, has been
fertilized and enhanced like few other scientific fields, by the incorporation of mathematical …
fertilized and enhanced like few other scientific fields, by the incorporation of mathematical …
Poly (3-hydroxybutyrate)-based nanoparticles for sorafenib and doxorubicin anticancer drug delivery
Dual drug-loaded nanotherapeutics can play an important role against the drug resistance
and side effects of the single drugs. Doxorubicin and sorafenib were efficiently co …
and side effects of the single drugs. Doxorubicin and sorafenib were efficiently co …
Efflux mechanism and pathway of verapamil pumping by human P-glycoprotein
L Wang, Y Sun - Archives of biochemistry and biophysics, 2020 - Elsevier
Multidrug resistance (MDR) caused by overexpressed permeability–glycoprotein (P-gp) in
cancer cells is the main barrier for the cure of cancers. P-gp can pump many …
cancer cells is the main barrier for the cure of cancers. P-gp can pump many …
Efflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations
Understanding the precise mechanistic details of the possible binding and transport of
antiseizure medications (ASMs) through the P-glycoprotein (P-gp) efflux pump is essential to …
antiseizure medications (ASMs) through the P-glycoprotein (P-gp) efflux pump is essential to …
Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability
EL Wilkinson, JE Sidaway, MJ Cross - Biology open, 2016 - journals.biologists.com
Cardiotoxicity induced by anti-cancer therapeutics is a severe, and potentially fatal, adverse
reaction of the heart in response to certain drugs. Current in vitro approaches to assess …
reaction of the heart in response to certain drugs. Current in vitro approaches to assess …
Molecular dynamics study on DNA nanotubes as drug delivery vehicle for anticancer drugs
In recent years, self-assembled DNA nanotubes have emerged as a type of nano-
biomaterials with great potential for biomedical applications. To develop universal …
biomaterials with great potential for biomedical applications. To develop universal …
Extended-ensemble docking to probe dynamic variation of ligand binding sites during large-scale structural changes of proteins
K Kapoor, S Thangapandian, E Tajkhorshid - Chemical Science, 2022 - pubs.rsc.org
Proteins can sample a broad landscape as they undergo conformational transition between
different functional states. At the same time, as key players in almost all cellular processes …
different functional states. At the same time, as key players in almost all cellular processes …
Efflux proteins at the blood–brain barrier: review and bioinformatics analysis
Efflux proteins at the blood–brain barrier provide a mechanism for export of waste products
of normal metabolism from the brain and help to maintain brain homeostasis. They also …
of normal metabolism from the brain and help to maintain brain homeostasis. They also …
Structural and dynamic perspectives on the promiscuous transport activity of P-glycoprotein
The multidrug transporter P-glycoprotein (P-gp) is expressed in the blood-brain barrier
endothelium where it effluxes a range of drug substrates, preventing their accumulation …
endothelium where it effluxes a range of drug substrates, preventing their accumulation …