[HTML][HTML] An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

E Lee, H Korf, A Vidal-Puig - Journal of hepatology, 2023 - Elsevier
Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

Therapeutic implications of targeting autophagy and TGF-β crosstalk for the treatment of liver fibrosis

S Siapoush, R Rezaei, H Alavifard, B Hatami, MR Zali… - Life Sciences, 2023 - Elsevier
Liver fibrosis is characterized by the excessive deposition and accumulation of extracellular
matrix components, mainly collagens, and occurs in response to a broad spectrum of …

[HTML][HTML] Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments

L Petagine, MG Zariwala, VB Patel - World Journal of …, 2023 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a
leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at …

The role of the immune system in the pathogenesis of NAFLD and potential therapeutic impacts of mesenchymal stem cell-derived extracellular vesicles

Z Moayedfard, F Sani, A Alizadeh… - Stem cell research & …, 2022 - Springer
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by intra-hepatocyte
triglyceride accumulation and concomitant involvement of the immune system with …

Liver fibrosis: Extracellular vesicles mediated intercellular communication in perisinusoidal space

E Devaraj, E Perumal, R Subramaniyan… - …, 2022 - Wiley Online Library
Liver disease is responsible for approximately 1.2 million global deaths per year, which
account for 3.5% of all deaths worldwide.[1] Acute liver injury is often reversible, while …

Adipose-derived mesenchymal stem cell-secreted extracellular vesicles alleviate non-alcoholic fatty liver disease via delivering miR-223-3p

Q Niu, T Wang, Z Wang, F Wang, D Huang, H Sun… - Adipocyte, 2022 - Taylor & Francis
Increasing studies have identified the potential of mesenchymal stem cell-derived
extracellular vesicles (MSC-EVs) in non-alcoholic fatty liver disease (NAFLD) treatment …

Genetic polymorphisms and diversity in nonalcoholic fatty liver disease (NAFLD): a mini Review

SA Sulaiman, V Dorairaj, MNH Adrus - Biomedicines, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a common liver disease with a wide spectrum of
liver conditions ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH) …

Nonalcoholic fatty liver disease (NAFLD): pathogenesis and noninvasive diagnosis

V Dorairaj, SA Sulaiman, N Abu, NA Abdul Murad - Biomedicines, 2021 - mdpi.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) or metabolic associated
fatty liver disease (MAFLD), as it is now known, has gradually increased. NAFLD is a …

[HTML][HTML] Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis

F Yang, Y Wu, Y Chen, J Xi, Y Chu, J Jin, Y Yan - JHEP Reports, 2023 - Elsevier
Abstract Background & Aims Non-alcoholic fatty liver disease (NAFLD) affects nearly a
quarter of the population with no approved pharmacological therapy. Liver steatosis is a …

Organ crosstalk and the modulation of insulin signaling

A Romero, J Eckel - Cells, 2021 - mdpi.com
A highly complex network of organ communication plays a key role in regulating metabolic
homeostasis, specifically due to the modulation of the insulin signaling machinery. As a …