Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Even
when patients survive the initial insult, there is significant morbidity and mortality secondary …

Perioperative acute lung injury (ALI) is a syndrome characterised by hypoxia and chest
radiograph changes. It is a serious post-operative complication, associated with …

Administration of bolus intravenous fluids, common in pre-hospital and hospitalised patients,
is associated with increased lung vascular permeability and mortality outside underlying …

Recently, buffered salt solutions and 20% albumin (small volume resuscitation) have been
advocated as an alternative fluid for intravenous resuscitation. The relative comparative …

Administration of bolus intravenous fluid is associated with respiratory dysfunction and
increased mortality, findings with no clear mechanistic explanation. The objective of this …

Background Induced hypernatremia and hyperosmolarity is protective in animal models of
lung injury. We hypothesized that increasing and maintaining plasma sodium between 145 …

Background and objective High serum osmolarity has been shown to be lung protective.
There is lack of clinical studies evaluating the impact on outcomes such as mortality. We …

Background: Dysnatraemias are commonly reported in COVID-19. However, the clinical
epidemiology of hypernatraemia and its impact on clinical outcomes in relation to different …

Purpose: Diagnostic radiation is an important part of patient care in the Intensive Care Unit;
however, there is little data on the acute effects of exposure to these doses. We investigated …

Introduction: Hypertonic sodium chloride solutions and liposomal drugs with pulmotropic
effect are of great interest for the treatment of acute lung injury (ALI). The results of the …