Omics-based interdisciplinarity is accelerating plant breeding
Y Shen, G Zhou, C Liang, Z Tian - Current Opinion in Plant Biology, 2022 - Elsevier
Plant breeding is one of the oldest and most important activities accompanying human
civilization. During the past thousand years, plant breeding has achieved three significant …
civilization. During the past thousand years, plant breeding has achieved three significant …
Recent insights into the genotype–phenotype relationship from massively parallel genetic assays
With the molecular revolution in Biology, a mechanistic understanding of the genotype–
phenotype relationship became possible. Recently, advances in DNA synthesis and …
phenotype relationship became possible. Recently, advances in DNA synthesis and …
Yeast 5 – an expanded reconstruction of the Saccharomyces cerevisiae metabolic network
Background Efforts to improve the computational reconstruction of the Saccharomyces
cerevisiae biochemical reaction network and to refine the stoichiometrically constrained …
cerevisiae biochemical reaction network and to refine the stoichiometrically constrained …
Genome scale models of yeast: towards standardized evaluation and consistent omic integration
BJ Sánchez, J Nielsen - Integrative Biology, 2015 - academic.oup.com
Genome scale models (GEMs) have enabled remarkable advances in systems biology,
acting as functional databases of metabolism, and as scaffolds for the contextualization of …
acting as functional databases of metabolism, and as scaffolds for the contextualization of …
Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway
Our ability to predict the impact of mutations on traits relevant for disease and evolution
remains severely limited by the dependence of their effects on the genetic background and …
remains severely limited by the dependence of their effects on the genetic background and …
Improved discovery of genetic interactions using CRISPRiSeq across multiple environments
Large-scale genetic interaction (GI) screens in yeast have been invaluable for our
understanding of molecular systems biology and for characterizing novel gene function …
understanding of molecular systems biology and for characterizing novel gene function …
SNPeffect: identifying functional roles of SNPs using metabolic networks
D Sarkar, CD Maranas - The Plant Journal, 2020 - Wiley Online Library
Genetic sources of phenotypic variation have been a focus of plant studies aimed at
improving agricultural yield and understanding adaptive processes. Genome‐wide …
improving agricultural yield and understanding adaptive processes. Genome‐wide …
[HTML][HTML] The impact of ALDH7A1 variants in oral cancer development and prognosis
HJ Lu, CY Chuang, MK Chen, CW Su, WE Yang… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
The gene encoding aldehyde dehydrogenase 7 family member A1 (ALDH7A1) has been
associated with the development and prognosis in multiple cancers; however, the role of …
associated with the development and prognosis in multiple cancers; however, the role of …
Flux balance analysis with or without molecular crowding fails to predict two thirds of experimentally observed epistasis in yeast
Computational predictions of double gene knockout effects by flux balance analysis (FBA)
have been used to characterized genome-wide patterns of epistasis in microorganisms …
have been used to characterized genome-wide patterns of epistasis in microorganisms …
Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid
Human serum uric acid concentration (SUA) is a complex trait. A recent meta-analysis of
multiple genome-wide association studies (GWAS) identified 28 loci associated with SUA …
multiple genome-wide association studies (GWAS) identified 28 loci associated with SUA …