Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators

E Piccinin, G Villani, A Moschetta - Nature reviews Gastroenterology & …, 2019 - nature.com
Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …

[HTML][HTML] Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Y Takahashi, Y Soejima, T Fukusato - World journal of …, 2012 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH) …

Animal models of nonalcoholic steatohepatitis: eat, delete, and inflame

SH Ibrahim, P Hirsova, H Malhi, GJ Gores - Digestive diseases and …, 2016 - Springer
With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public
health problem with increasing prevalence. The mechanism of disease progression remains …

Nonalcoholic fatty liver disease in children: unique considerations and challenges

D Goldner, JE Lavine - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence in concert with the
global epidemic of obesity and is being diagnosed at increasingly younger ages. The …

The progression and natural history of pediatric nonalcoholic fatty liver disease

NP Goyal, JB Schwimmer - Clinics in liver disease, 2015 - pmc.ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in the United States. Childhood NAFLD is associated with hepatic and non-hepatic morbidity …

PFOS-induced hepatic steatosis, the mechanistic actions on β-oxidation and lipid transport

HT Wan, YG Zhao, X Wei, KY Hui, JP Giesy… - … et Biophysica Acta (BBA …, 2012 - Elsevier
BACKGROUND: Perfluorooctane sulfonate (PFOS) was produced by various industries and
was widely used in diverse consumer products. Human sample analysis indicated PFOS …

Mechanisms of lipotoxicity in NAFLD and clinical implications

SH Ibrahim, R Kohli, GJ Gores - Journal of pediatric …, 2011 - journals.lww.com
With the epidemic of childhood obesity, nonalcoholic fatty liver disease (NAFLD) has
become the most common cause of chronic liver disease in pediatrics. NAFLD is strongly …

[PDF][PDF] Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients

M Noureddin, KP Yates, IA Vaughn… - …, 2013 - Wiley Online Library
The characteristics of nonalcoholic fatty liver disease (NAFLD) in elderly patients are
unknown. Therefore, we aimed to examine the differences between elderly and nonelderly …

Non-alcoholic fatty liver disease in obese youth with insulin resistance and type 2 diabetes

S Scapaticci, E D'Adamo, A Mohn, F Chiarelli… - Frontiers in …, 2021 - frontiersin.org
Currently, Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent form of chronic
liver disease in children and adolescents worldwide. Simultaneously to the epidemic …

Zonation of glucose and fatty acid metabolism in the liver: mechanism and metabolic consequences

BS Hijmans, A Grefhorst, MH Oosterveer, AK Groen - Biochimie, 2014 - Elsevier
The liver is generally considered as a relatively homogeneous organ containing four
different cell types. It is however well-known that the liver is not homogeneous and consists …