Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens

P Mews, L Sosnick, A Gurung, S Sidoli, EJ Nestler - Science Signaling, 2024 - science.org
Cocaine use disorder (CUD) is a chronic neuropsychiatric condition that results from
enduring cellular and molecular adaptations. Among substance use disorders, CUD is …

Exploring the progression of drug dependence in a methamphetamine self-administration rat model through targeted and non-targeted metabolomics analyses

SH Song, S Kim, WJ Jang, IS Ryu, CH Jeong, S Lee - Scientific Reports, 2024 - nature.com
Persistent neurochemical and biological disturbances resulting from repeated cycles of drug
reward, withdrawal, and relapse contribute to drug dependence. Methamphetamine (MA) is …

Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses

GA Pathak, R Pietrzak, AM Lacobelle, C Overstreet… - medRxiv, 2024 - medrxiv.org
Objective: This study investigated the genetic and epigenetic mechanisms underlying the
comorbidity patterns of five substance dependence diagnoses (SDs; alcohol, AD; cannabis …