Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
Nonhomologous end joining in yeast
JM Daley, PL Palmbos, D Wu, TE Wilson - Annu. Rev. Genet., 2005 - annualreviews.org
Nonhomologous end joining (NHEJ), the direct rejoining of DNA double-strand breaks, is
closely associated with illegitimate recombination and chromosomal rearrangement. This …
closely associated with illegitimate recombination and chromosomal rearrangement. This …
Structural basis of long-range to short-range synaptic transition in NHEJ
DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the
incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …
incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
P Ahnesorg, P Smith, SP Jackson - Cell, 2006 - cell.com
DNA nonhomologous end-joining (NHEJ) is a predominant pathway of DNA double-strand
break repair in mammalian cells, and defects in it cause radiosensitivity at the cellular and …
break repair in mammalian cells, and defects in it cause radiosensitivity at the cellular and …
Eukaryotic DNA ligases: structural and functional insights
T Ellenberger, AE Tomkinson - Annu. Rev. Biochem., 2008 - annualreviews.org
DNA ligases are required for DNA replication, repair, and recombination. In eukaryotes,
there are three families of ATP-dependent DNA ligases. Members of the DNA ligase I and IV …
there are three families of ATP-dependent DNA ligases. Members of the DNA ligase I and IV …
A biochemically defined system for mammalian nonhomologous DNA end joining
Y Ma, H Lu, B Tippin, MF Goodman, N Shimazaki… - Molecular cell, 2004 - cell.com
Nonhomologous end joining (NHEJ) is a major pathway in multicellular eukaryotes for
repairing double-strand DNA breaks (DSBs). Here, the NHEJ reactions have been …
repairing double-strand DNA breaks (DSBs). Here, the NHEJ reactions have been …
Cohesins localize with CTCF at the KSHV latency control region and at cellular c‐myc and H19/Igf2 insulators
W Stedman, H Kang, S Lin, JL Kissil… - The EMBO …, 2008 - embopress.org
Cohesins, which mediate sister chromatin cohesion, and CTCF, which functions at
chromatin boundaries, play key roles in the structural and functional organization of …
chromatin boundaries, play key roles in the structural and functional organization of …
The mechanism of non-homologous end-joining: a synopsis of synapsis
E Weterings, DC Van Gent - DNA repair, 2004 - Elsevier
Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is
required for resistance to genotoxic agents, such as ionizing radiation, but also for proper …
required for resistance to genotoxic agents, such as ionizing radiation, but also for proper …
APLF promotes the assembly and activity of non‐homologous end joining protein complexes
Non‐homologous end joining (NHEJ) is critical for the maintenance of genetic integrity and
DNA double‐strand break (DSB) repair. NHEJ is regulated by a series of interactions …
DNA double‐strand break (DSB) repair. NHEJ is regulated by a series of interactions …
The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage
P Reynolds, JA Anderson, JV Harper… - Nucleic acids …, 2012 - academic.oup.com
DNA double-strand breaks (DSBs) are biologically one of the most important cellular lesions
and possess varying degrees of chemical complexity. The notion that the repairability of …
and possess varying degrees of chemical complexity. The notion that the repairability of …