M Richner, M Ulrichsen, SL Elmegaard, R Dieu… - Molecular …, 2014 - Springer
Peripheral nerve injury disrupts the normal functions of sensory and motor neurons by damaging the integrity of axons and Schwann cells. In contrast to the central nervous …
R Torres-Rosas, G Yehia, G Peña, P Mishra… - Nature medicine, 2014 - nature.com
Previous anti-inflammatory strategies against sepsis, a leading cause of death in hospitals, had limited efficacy in clinical trials, in part because they targeted single cytokines and the …
S Huang, Z Zhang, E Gambeta, SC Xu, C Thomas… - Cell Reports, 2020 - cell.com
The medial prefrontal cortex (mPFC) is a brain region involved in the affective components of pain and undergoes plasticity during the development of chronic pain. Dopamine (DA) is …
S Wedel, P Mathoor, O Rauh, T Heymann… - Journal of …, 2022 - Springer
Background Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options …
SE Jager, LT Pallesen, M Richner, P Harley, Z Hore… - Glia, 2020 - Wiley Online Library
Satellite glial cells (SGCs) are homeostatic cells enveloping the somata of peripheral sensory and autonomic neurons. A wide variety of neuronal stressors trigger activation of …
The dynamic expansions and contractions of the microglia population in the central nervous system (CNS) to achieve homeostasis are likely vital for their function. Microglia respond to …
A Bhattacherjee, C Zhang, BR Watson… - Nature …, 2023 - nature.com
The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions ranging from cognition, emotion and executive action to even pain processing. To decode …
TS Nelson, GP Sinha, DFS Santos… - Proceedings of the …, 2022 - National Acad Sciences
Peripheral nerve injury sensitizes a complex network of spinal cord dorsal horn (DH) neurons to produce allodynia and neuropathic pain. The identification of a druggable target …
I Yalcin, S Megat, F Barthas, E Waltisperger… - JoVE (Journal of …, 2014 - jove.com
Neuropathic pain arises as a consequence of a lesion or a disease affecting the somatosensory system. This syndrome results from maladaptive changes in injured sensory …