The risk factors for Graves' ophthalmopathy

J Cao, Y Su, Z Chen, C Ma, W Xiong - Graefe's Archive for Clinical and …, 2022 - Springer
Purpose This review aimed to provide an overview of current research into the risk factors for
Graves' ophthalmopathy (GO). Methods To find information about the risk factors for GO, the …

Thyroid peroxidase as a dual active site enzyme: Focus on biosynthesis, hormonogenesis and thyroid disorders of autoimmunity and cancer

M Godlewska, PJ Banga - Biochimie, 2019 - Elsevier
Thyroid peroxidase (TPO) is the key enzyme involved in thyroid hormone synthesis.
Autoantibodies to TPO (TPOAbs) are a hallmark of autoimmune thyroid disease (AITD) …

Significance of HLA in the development of Graves' orbitopathy

M Stasiak, K Zawadzka-Starczewska, B Tymoniuk… - Genes & …, 2023 - nature.com
Abstract Graves' disease (GD), similarly to most autoimmune disease, is triggered by
environmental factors in genetically predisposed individuals. Particular HLA alleles increase …

[HTML][HTML] Genotype-phenotype correlations in Graves' disease

M Radziszewski, A Kuś, T Bednarczuk - Best practice & research Clinical …, 2023 - Elsevier
Graves' disease (GD) is a heterogeneous autoimmune disease affecting with varying
degrees of severity the thyroid gland, orbital tissues and skin. The pathogenesis of GD …

Thyroid‐associated orbitopathy and biomarkers: where we are and what we can hope for the future

N Turck, S Eperon, M De Los Angeles Gracia… - Disease …, 2018 - Wiley Online Library
Background. Thyroid‐associated orbitopathy (TAO) is the most common autoimmune
disease of the orbit. It occurs more often in patients presenting with hyperthyroidism …

Significance of HLA in Graves' disease and Graves' orbitopathy in Asian and Caucasian populations–a systematic review

M Stasiak, B Stasiak… - Frontiers in …, 2023 - frontiersin.org
Introduction Graves' disease (GD) and Graves' orbitopathy (GO) development were
suspected to be HLA-related in both Asian and Caucasian populations. However, most …

Graves' disease: introducing new genetic and epigenetic contributors

E Razmara, M Salehi, S Aslani… - Journal of …, 2021 - jme.bioscientifica.com
Autoimmune thyroid disease (AITD) accounts for 90% of all thyroid diseases and affects 2–
5% of the population with remarkable familial clustering. Among AITDs, Graves' disease …

Thyroid Peroxidase Revisited–Whatʼs New?

M Godlewska, D Gawel, AM Buckle… - Hormone and …, 2019 - thieme-connect.com
Thyroid peroxidase (TPO) is an enzyme that participates in thyroid hormone biosynthesis.
TPO is also a major autoantigen in autoimmune thyroid diseases (AITD). In this review, we …

Paediatric‐onset and adult‐onset Graves' disease share multiple genetic risk factors

A Kuś, M Radziszewski, A Glina… - Clinical …, 2019 - Wiley Online Library
Background Graves' disease (GD) is an autoimmune thyroid disease (AITD) with a peak
incidence between 30 and 50 years of age. Although children and adolescents may also …

The role of TPOAb in thyroid-associated orbitopathy: a systematic review

G Kyriakos, A Patsouras, E Voutyritsa… - Ocular Immunology …, 2022 - Taylor & Francis
Introduction Thyroid-associated orbitopathy (TAO) is one of the most common autoimmune
inflammatory disorders of the orbit. The presence of anti-thyroid antibodies is believed to …