Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

The protein α-synuclein has a central role in the pathogenesis of Parkinson's disease. Like
that of other proteins that accumulate in neurodegenerative disease, however, the function …

Glucocerebrosidase 1 (GBA) mutations responsible for Gaucher disease (GD) are the most
common genetic risk factor for Parkinson's disease (PD). Although the genetic link between …

Genetic and pathological studies link α-synuclein to the etiology of Parkinson's disease
(PD), but the normal function of this presynaptic protein remains unknown. α-Synuclein, an …

Although the physiological function of α‐synuclein is not fully understood, it has been
suggested to primarily localize to the presynaptic terminals of mature neurons, where it …

The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …

Latrophilin-1,-2, and-3 are adhesion-type G protein-coupled receptors that are auxiliary α-
latrotoxin receptors, suggesting that they may have a synaptic function. Using pulldowns, we …

Synucleins are a family of presynaptic membrane binding proteins. α-Synuclein, the
principal member of this family, is mutated in familial Parkinson disease. To gain insight into …

Maintenance of protein homeostasis is vitally important in post-mitotic cells, particularly
neurons. Neurodegenerative diseases such as polyglutamine expansion disorders—like …