Synthetic glycans to improve current glycoconjugate vaccines and fight antimicrobial resistance

L Del Bino, KE Østerlid, DY Wu, F Nonne… - Chemical …, 2022 - ACS Publications
Antimicrobial resistance (AMR) is emerging as the next potential pandemic. Different
microorganisms, including the bacteria Acinetobacter baumannii, Clostridioides difficile …

Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options

CR Lee, JH Lee, M Park, KS Park, IK Bae… - Frontiers in cellular …, 2017 - frontiersin.org
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible
for hospital-acquired nosocomial infections in the modern healthcare system. Due to the …

The Mechanisms of Disease Caused by Acinetobacter baumannii

FC Morris, C Dexter, X Kostoulias, MI Uddin… - Frontiers in …, 2019 - frontiersin.org
Acinetobacter baumannii is a Gram negative opportunistic pathogen that has demonstrated
a significant insurgence in the prevalence of infections over recent decades. With only a …

Antibiotic Modulation of Capsular Exopolysaccharide and Virulence in Acinetobacter baumannii

E Geisinger, RR Isberg - PLoS pathogens, 2015 - journals.plos.org
Acinetobacter baumannii is an opportunistic pathogen of increasing importance due to its
propensity for intractable multidrug-resistant infections in hospitals. All clinical isolates …

Identification of Acinetobacter baumannii loci for capsular polysaccharide (KL) and lipooligosaccharide outer core (OCL) synthesis in genome assemblies using curated …

KL Wyres, SM Cahill, KE Holt, RM Hall… - Microbial …, 2019 - microbiologyresearch.org
Multiply antibiotic-resistant Acinetobacter baumannii infections are a global public health
concern and accurate tracking of the spread of specific lineages is needed. Variation in the …

Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges

D Wong, TB Nielsen, RA Bonomo… - Clinical microbiology …, 2017 - Am Soc Microbiol
Acinetobacter is a complex genus, and historically, there has been confusion about the
existence of multiple species. The species commonly cause nosocomial infections …

Diversity and Function of Capsular Polysaccharide in Acinetobacter baumannii

JK Singh, FG Adams, MH Brown - Frontiers in microbiology, 2019 - frontiersin.org
The Gram-negative opportunistic bacterium Acinetobacter baumannii is a significant cause
of hospital-borne infections worldwide. Alarmingly, the rapid development of antimicrobial …

Mapping Global Prevalence of Acinetobacter baumannii and Recent Vaccine Development to Tackle It

C Ma, S McClean - Vaccines, 2021 - mdpi.com
Acinetobacter baumannii is a leading cause of nosocomial infections that severely threaten
public health. The formidable adaptability and resistance of this opportunistic pathogen have …

Potential targets for next generation antimicrobial glycoconjugate vaccines

F Micoli, P Costantino, R Adamo - FEMS microbiology reviews, 2018 - academic.oup.com
Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

Variation in the Complex Carbohydrate Biosynthesis Loci of Acinetobacter baumannii Genomes

JJ Kenyon, RM Hall - PloS one, 2013 - journals.plos.org
Extracellular polysaccharides are major immunogenic components of the bacterial cell
envelope. However, little is known about their biosynthesis in the genus Acinetobacter …