Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of
cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in …

The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

Intravasation is a key step in cancer metastasis during which tumor cells penetrate the
vessel wall and enter circulation, thereby becoming circulating tumor cells and potential …

T cells are critical orchestrators of the adaptive immune response that optimally eliminate a
specific pathogen. Aberrant T-cell development and function are implicated in a broad range …

Rheumatoid arthritis (RA) is a highly disabling, systemic autoimmune disease. It presents a
remarkable tendency to recur, which renders it almost impossible for patients to live without …

Cancer development is a multistep process in which cells must overcome a series of
obstacles before they can become fully developed tumors. First, cells must develop the …

Although CD31 expression on human thymocytes has been reported, a detailed analysis of
CD31 expression at various stages of T cell development in the human thymus is missing. In …

Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its
metastatic potency. Despite remarkable breakthroughs in term of treatments with the …

The role of sphingosine-1 phosphate (S1P) in leukocyte trafficking has been well
deciphered in mice but remains largely unaddressed in humans. In this study, we assessed …

Sphingolipids (SLs) are a class of essential, bioactive lipids. The SL family includes over
4000 distinct molecules, characterized by their sphingoid base (long-chain aliphatic amine) …