The gut–liver axis and gut microbiota in health and liver disease

CL Hsu, B Schnabl - Nature Reviews Microbiology, 2023 - nature.com
The trillions of microorganisms in the human intestine are important regulators of health, and
disruptions in the gut microbial communities can cause disease. The gut, liver and immune …

The immunology of sepsis

T van der Poll, M Shankar-Hari, WJ Wiersinga - Immunity, 2021 - cell.com
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Transfer learning enables predictions in network biology

CV Theodoris, L Xiao, A Chopra, MD Chaffin… - Nature, 2023 - nature.com
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …

Butyrate producers,“The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

V Singh, GD Lee, HW Son, H Koh, ES Kim… - Frontiers in …, 2023 - frontiersin.org
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological
importance than the other major SCFAs (acetate and propionate). Most butyrate producers …

Health benefits and side effects of short-chain fatty acids

RG Xiong, DD Zhou, SX Wu, SY Huang, A Saimaiti… - Foods, 2022 - mdpi.com
The gut microbiota and their metabolites could play an important role in health and diseases
of human beings. Short-chain fatty acids (SCFAs) are mainly produced by gut microbiome …

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

D Erny, N Dokalis, C Mezö, A Castoldi, O Mossad… - Cell Metabolism, 2021 - cell.com
As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …

Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

SCFA: mechanisms and functional importance in the gut

C Martin-Gallausiaux, L Marinelli… - Proceedings of the …, 2021 - cambridge.org
In recent years, the importance of the gut microbiota in human health has been revealed and
many publications have highlighted its role as a key component of human physiology …

Epigenetic regulation by gut microbiota

V Woo, T Alenghat - Gut microbes, 2022 - Taylor & Francis
The gastrointestinal tract is continuously exposed to trillions of commensal microbes,
collectively termed the microbiota, which are environmental stimuli that can direct health and …