Aspartate in tumor microenvironment and beyond: metabolic interactions and therapeutic perspectives

JW Soon, MA Manca, A Laskowska, J Starkova… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Aspartate is a proteinogenic non-essential amino acid with several essential functions in
proliferating cells. It is mostly produced in a cell autonomous manner from oxalacetate via …

Illuminating anions in biology with genetically encoded fluorescent biosensors

MA Cook, SM Phelps, JN Tutol, DA Adams… - Current Opinion in …, 2025 - Elsevier
Highlights•Boom of genetically encoded fluorescent biosensors to illuminate anions in
biology.•Approaches to design and engineer anion biosensors.•Biosensors for chloride …

Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak–Keller–Segel chemotaxis model

TV Phan, HH Mattingly, L Vo… - Proceedings of the …, 2024 - National Acad Sciences
Chemotactic bacteria not only navigate chemical gradients, but also shape their
environments by consuming and secreting attractants. Investigating how these processes …

AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells

L Hellweg, M Pfeifer, M Tarnawski, S Thing-Teoh… - Cell chemical …, 2024 - cell.com
Aspartate is crucial for nucleotide synthesis, ammonia detoxification, and maintaining redox
balance via the malate-aspartate-shuttle (MAS). To disentangle these multiple roles of …

A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA

BL Ranzau, TD Robinson, JM Scully… - ACS Bio & Med …, 2024 - ACS Publications
Malonyl-CoA is the essential building block of fatty acids and regulates cell function through
protein malonylation and allosteric regulation of signaling networks. Accordingly, the …

[PDF][PDF] CA, USA 5These authors contributed equally

BL Ranzau, TD Robinson, JM Scully, ED Kapelczack… - biorxiv.org
Malonyl-CoA is the essential building block of fatty acids and regulates cell function through
protein malonylation and allosteric regulation of signaling networks. Accordingly, the …