Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

Many important cell types in adult vertebrates have a mesenchymal origin, including
fibroblasts and vascular mural cells. Although their biological importance is undisputed, the …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through …

Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared
toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient …

Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis
(UC). To understand their cell type specificities and pathways of action, we generate an atlas …

Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Intestinal organoids are complex three-dimensional structures that mimic the cell-type
composition and tissue organization of the intestine by recapitulating the self-organizing …

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …

The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme,
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and …