This review explores the limitations of self-reported race, ethnicity, and genetic ancestry in
biomedical research. Various terminologies are used to classify human differences in …

Human eye color is highly heritable, but its genetic architecture is not yet fully understood.
We report the results of the largest genome-wide association study for eye color to date …

Background Psoriasis is an immune-mediated inflammatory skin disease with a strong
genetic background in which activation of IL-17 signaling is central in the pathogenesis …

Modern European genetic structure demonstrates strong correlations with geography, while
genetic analysis of prehistoric humans has indicated at least two major waves of immigration …

Admixed populations arise when two or more previously isolated populations interbreed.
Mapping asthma susceptibility loci in an admixed population using admixture mapping (AM) …

HLA-C remains the strongest susceptibility candidate gene in psoriasis. Evidence for
interaction between HLA-C and endoplasmic reticulum aminopeptidase 1 (ERAP1) confined …

The Brazilian population was formed by extensive admixture of three different ancestral
roots: Amerindians, Europeans and Africans. Our previous work has shown that at an …

Psoriasis is clinically heterogeneous, and symptoms can vary from mild almost cosmetic
symptoms to severe disease requiring systemic therapy. Biomarkers predicting disease …

The genetic history of prehistoric and protohistoric Korean populations is not well
understood because only a small number of ancient genomes are available. Here, we report …

Most psoriasis susceptibility genes were identified in cohorts of mixed clinical phenotypes
and the exploration of genes in clinical subtypes is scarce. IL-22 has an established role in …