Sulfonamides have been in clinical use for many years, and the development of bioactive
substances containing the sulfonamide subunit has grown steadily in view of their important …

Protein kinases have essential responsibilities in controlling several cellular processes, and
their abnormal regulation is strongly related to the development of cancer. The …

One of the leading causes of mortality in the world is cancer. This disease occurs when
responsible genes that regulate the cell cycle become inactive due to internal or external …

Novel series of diphenyl-1H-pyrazoles (4a-g) and pyrazolo [3, 4-b] pyridines (5a-g and 7a-i)
were synthesized and evaluated for their antiproliferative activity against breast cancer cell …

Cancer is one of the major leading causes of death worldwide despite many breakthroughs
in the development of novel anticancer drugs. The heterodimer CDK-Cyclin complex plays …

Abstract A novel series of 2, 4-dichlorophenoxymethyl-based derivatives 4-18 bearing
various nitrogenous heterocyclic systems have been designed and synthesized through …

New diphenyl-1H-pyrazoles were synthesized and screened for CDK2 inhibition where 8d,
9b, 9c, and 9e exhibited promising activity (IC 50= 51.21, 41.36, 29.31, and 40.54 nM …

One of the biggest problems facing contemporary medicine is cancer. New approaches to
therapy are required due to the difficult and prolonged treatment, the numerous adverse …

New sulfonamide derivatives have been synthesized and tested as antitumor agents. All
newly synthesized compounds were tested in vitro against 60 lines of human cancer cells …

Abstract CDK2 (cyclin-dependent kinase 2), a member of the CDK family, has been shown
to play a role in many cellular activities including cell cycle progression, apoptosis and …