Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

A critical review of the development of specific chemotherapeutic approaches for the
management of American Trypanosomiasis or Chagas disease is presented, including …

We present herein the first visible-light-driven hydrocarboxylation as well as
carbocarboxylation of alkynes using CO2 via an iridium/cobalt dual catalysis. Such …

In the modern scenario, the quinolone scaffold has emerged as a very potent motif
considering its clinical significance. Quinolones possess wide range of pharmacological …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

This article presents an overview of the currently available drugs nifurtimox (NFX) and
benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas …

Endemic throughout Latin America with a prevalence rate of approximately 1.4%, Chagas
disease (CD) is estimated to kill 14,000 people every year, which is more people in the …

Trypanosoma cruzi and Trypanosoma brucei are parasites that cause Chagas' disease and
African sleeping sickness, respectively. Both parasites rely on essential cysteine proteases …

Despite the wealth of knowledge regarding the mechanisms of action and the mechanisms
of resistance to azole antifungals, very little is known about how the azoles are imported into …

Neglected diseases are a major global cause of illness, long-term disability and death.
Chagas' disease is a parasitic infection widely distributed throughout Latin America, with …