Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …
key observation is the disruption of cellular homeostasis, often coinciding with disease …
Dyes and stains: from molecular structure to histological application
TV Veuthey, MG Herrera, VI Dodero - 2014 - ri.conicet.gov.ar
In the present review, the chemistry of dyes as well as the interaction mechanisms between
tissue and dye has been detailed, and also some of the key factors affecting the selectivity of …
tissue and dye has been detailed, and also some of the key factors affecting the selectivity of …
Targeting mitochondrial reactive oxygen species-mediated oxidative stress attenuates nicotine-induced cardiac remodeling and dysfunction
Long-term nicotine intake is associated with an increased risk of myocardial damage and
dysfunction. However, it remains unclear whether targeting mitochondrial reactive oxygen …
dysfunction. However, it remains unclear whether targeting mitochondrial reactive oxygen …
Troubleshooting the dichlorofluorescein assay to avoid artifacts in measurement of toxicant-stimulated cellular production of reactive oxidant species
LM Tetz, PW Kamau, AA Cheng, JD Meeker… - … of pharmacological and …, 2013 - Elsevier
INTRODUCTION: The dichlorofluorescein (DCF) assay is a popular method for measuring
cellular reactive oxidant species (ROS). Although caveats have been reported with the DCF …
cellular reactive oxidant species (ROS). Although caveats have been reported with the DCF …
A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke
Smoking cigarettes is harmful to the cardiovascular system. Considerable attention has
been paid to the reduced harm potential of alternative nicotine-containing inhalable …
been paid to the reduced harm potential of alternative nicotine-containing inhalable …
Nicotine induces cardiac toxicity through blocking mitophagic clearance in young adult rat
Since an outbreak of vaping-related deaths in the US has been reported as a public health
crisis, the cardiovascular safety of nicotine nowadays receives increasing attention due to …
crisis, the cardiovascular safety of nicotine nowadays receives increasing attention due to …
Tobacco and cardiovascular health
P Mainali, S Pant, AP Rodriguez, A Deshmukh… - Cardiovascular …, 2015 - Springer
Tobacco consumption has been inextricably intertwined with society and its evolution. At
one time, centuries ago, thought to be a sign of refinement and nobility, fortunately, this …
one time, centuries ago, thought to be a sign of refinement and nobility, fortunately, this …
Cardiac-specific overexpression of metallothionein rescues against cigarette smoking exposure-induced myocardial contractile and mitochondrial damage
Objectives Second hand cigarette smoke is an independent risk factor for cardiovascular
disease. Although a tie between smoking and cardiovascular disease is well established …
disease. Although a tie between smoking and cardiovascular disease is well established …
Beclin1 haploinsufficiency accentuates second-hand smoke exposure-induced myocardial remodeling and contractile dysfunction through a STING-mediated …
F Liu, Y Liu, Z Zhuang, J Ma, X Xu, W Zhang… - Journal of Molecular and …, 2020 - Elsevier
Second-hand smoking evokes inflammation and cardiovascular diseases. Recent evidence
has revealed a pivotal role for deranged autophagy in smoke exposure-induced cardiac …
has revealed a pivotal role for deranged autophagy in smoke exposure-induced cardiac …
Cathepsin K knockout protects against cardiac dysfunction in diabetic mice
Diabetes is a major risk factor for cardiovascular disease and the lysosomal cysteine
protease cathepsin K plays a critical role in cardiac pathophysiology. To expand upon our …
protease cathepsin K plays a critical role in cardiac pathophysiology. To expand upon our …