The ongoing characterization of the genetic and epigenetic alterations in the gliomas has
already improved the classification of these heterogeneous tumors and enabled the …

Simple Summary Although multiple meta-analyses on active specific immunotherapy
treatment for glioblastoma multiforme (GBM) have demonstrated a significant prolongation of …

Purpose: Glioblastoma is refractory to conventional therapies. The bromodomain and
extraterminal domain (BET) proteins are epigenetic readers that selectively bind to …

The molecular signaling pathways orchestrating the biology of cancer stem-like cells
(CSLCs), including glioblastoma, remain to be elucidated. We investigated in this study the …

Glioblastomas are progressive brain tumors with devastating proliferative and invasive
characteristics. Ion channels are the second largest target class for drug development. In this …

ABSTRACT Human miR-146b-5p is located on chromosome 10q24. 3. Loss of the 10q24–
26 region is frequently observed in gliomas. Here, we report that miR-146b-5p suppresses …

High Grade Gliomas (HGG) have a poor outcome, however, prognostic sub-groups of
patients may be individuated by some clinico-biological parameters. It was recently …

Glioblastoma multiforme (GBM) is the most common and lethal malignant primary brain
tumor. It is classified by the World Health Organization (WHO) in the group of diffusely …

Purpose The monoterpene perillyl alcohol (POH) a Ras inhibitor with potential capacity to
arrest gliomagenesis is being used in a phase I/II clinical trial in adults with recurrent …

The efficacy of glioblastoma chemotherapy is not satisfactory; therefore, a new medication is
expected to improve outcomes. As much evidence shows that antidepressants decrease …