Brain lipidomics: From functional landscape to clinical significance

JH Yoon, Y Seo, YS Jo, S Lee, E Cho… - Science …, 2022 - science.org
Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

Ambient ionization mass spectrometry: recent developments and applications

CL Feider, A Krieger, RJ DeHoog… - Analytical chemistry, 2019 - ACS Publications
The early 2000s brought a new age in the field of mass spectrometry (MS) with the
introduction of ambient ionization MS techniques. As defined by one of its early visionaries …

Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures

G Liebisch, E Fahy, J Aoki, EA Dennis, T Durand… - Journal of lipid …, 2020 - ASBMB
A comprehensive and standardized system to report lipid structures analyzed by MS is
essential for the communication and storage of lipidomics data. Herein, an update on both …

Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry

T Xia, F Zhou, D Zhang, X Jin, H Shi, H Yin… - Nature …, 2023 - nature.com
A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …

Recommendations for good practice in MS-based lipidomics

HC Köfeler, R Ahrends, ES Baker, K Ekroos, X Han… - Journal of lipid …, 2021 - ASBMB
In the last 2 decades, lipidomics has become one of the fastest expanding scientific
disciplines in biomedical research. With an increasing number of new research groups to …

Large-scale lipid analysis with C=C location and sn-position isomer resolving power

W Cao, S Cheng, J Yang, J Feng, W Zhang, Z Li… - Nature …, 2020 - nature.com
Lipids play a pivotal role in biological processes and lipid analysis by mass spectrometry
(MS) has significantly advanced lipidomic studies. While the structure specificity of lipid …

Dissociation of biomolecules by an intense low-energy electron beam in a high sensitivity time-of-flight mass spectrometer

T Baba, P Ryumin, E Duchoslav, K Chen… - Journal of the …, 2021 - ACS Publications
We report the progress on an electron-activated dissociation (EAD) device coupled to a
quadrupole TOF mass spectrometer (QqTOF MS) developed in our group. This device …

Pinpointing Double Bond and sn-Positions in Glycerophospholipids via Hybrid 193 nm Ultraviolet Photodissociation (UVPD) Mass Spectrometry

PE Williams, DR Klein, SM Greer… - Journal of the American …, 2017 - ACS Publications
Complete structural characterization of complex lipids, such as glycerophospholipids, by
tandem mass spectrometry (MS/MS) continues to present a major challenge. Conventional …

Ion mobility conformational lipid atlas for high confidence lipidomics

KL Leaptrot, JC May, JN Dodds, JA McLean - Nature communications, 2019 - nature.com
Lipids are highly structurally diverse molecules involved in a wide variety of biological
processes. Here, we use high precision ion mobility-mass spectrometry to compile a …