Isolation of extracellular vesicles: general methodologies and latest trends

MY Konoshenko, EA Lekchnov… - BioMed research …, 2018 - Wiley Online Library
Background. Extracellular vesicles (EVs) play an essential role in the communication
between cells and transport of diagnostically significant molecules. A wide diversity of …

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

JC Akers, D Gonda, R Kim, BS Carter… - Journal of neuro …, 2013 - Springer
Recent studies suggest both normal and cancerous cells secrete vesicles into the
extracellular space. These extracellular vesicles (EVs) contain materials that mirror the …

A comprehensive overview of exosomes as drug delivery vehicles—endogenous nanocarriers for targeted cancer therapy

KB Johnsen, JM Gudbergsson, MN Skov… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Exosomes denote a class of secreted nanoparticles defined by size, surface protein and
lipid composition, and the ability to carry RNA and proteins. They are important mediators of …

MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development

JC Akers, V Ramakrishnan, R Kim, J Skog, I Nakano… - PloS one, 2013 - journals.plos.org
Glioblastoma cells secrete extra-cellular vesicles (EVs) containing microRNAs (miRNAs).
Analysis of these EV miRNAs in the bio-fluids of afflicted patients represents a potential …

Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients

JM Figueroa, J Skog, J Akers, H Li, R Komotar… - Neuro …, 2017 - academic.oup.com
Background RNAs within extracellular vesicles (EVs) have potential as diagnostic
biomarkers for patients with cancer and are identified in a variety of biofluids. Glioblastomas …

The fusion of two worlds: Non-coding RNAs and extracellular vesicles-diagnostic and therapeutic implications

Y Sato-Kuwabara, SA Melo… - … journal of oncology, 2015 - spandidos-publications.com
The role of the extracellular non-coding RNAs, particularly microRNAs present in tumor-
derived extravesicles, has been intensively exploited in human cancer as a promising tool …

Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain

DM Pegtel, L Peferoen, S Amor - … Transactions of the …, 2014 - royalsocietypublishing.org
Homeostasis relies heavily on effective cell-to-cell communication. In the central nervous
system (CNS), probably more so than in other organs, such communication is crucial to …

Roles of microvesicles in tumor progression and clinical applications

S Zhu, S Li, M Yi, N Li, K Wu - International Journal of …, 2021 - Taylor & Francis
Microvesicles are extracellular vesicles with diameter ranging from 100 to 1000 nm that are
secreted by tumor cells or other cells in the tumor microenvironment. A growing number of …

The emergent role of exosomes in glioma

J Gourlay, AP Morokoff, RB Luwor, HJ Zhu… - Journal of Clinical …, 2017 - Elsevier
Extracellular vesicles (EVs) are known mediators of intercellular communication for both
normal and tumour cells. With the capability to transfer nucleic acids, proteins and lipids …

[HTML][HTML] A cerebrospinal fluid microRNA signature as biomarker for glioblastoma

JC Akers, W Hua, H Li, V Ramakrishnan, Z Yang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Results miRNA profiles from clinical CSF correlated with those found in glioblastoma
tissues. Comparison of CSF miRNA profiles between glioblastoma patients and non-brain …