Biomedical applications of calixarenes: state of the art and perspectives

YC Pan, XY Hu, DS Guo - Angewandte Chemie International …, 2021 - Wiley Online Library
Calixarenes (CAs), representing the third generation of supramolecular hosts and one of the
most widely studied macrocyclic scaffolds, offer (almost) unlimited structure and application …

Histones: at the crossroads of peptide and protein chemistry

MM Müller, TW Muir - Chemical reviews, 2015 - ACS Publications
1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …

Micromolar Affinity and Higher: Synthetic Host–Guest Complexes with High Stabilities

S Sarkar, P Ballester, M Spektor… - Angewandte Chemie …, 2023 - Wiley Online Library
The design of high‐affinity synthetic host–guest complexes is of paramount importance
because they are key elements in constructing unprecedented supramolecular assemblies …

Polycomb-mediated silencing in neuroendocrine prostate cancer

PL Clermont, D Lin, F Crea, R Wu, H Xue, Y Wang… - Clinical …, 2015 - Springer
Background Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of
prostate cancer (PCa) for which the median survival remains less than a year. Current …

Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain

C Ren, K Morohashi, AN Plotnikov, J Jakoncic… - Chemistry & biology, 2015 - cell.com
Summary Chromobox homolog 7 (CBX7) plays an important role in gene transcription in a
wide array of cellular processes, ranging from stem cell self-renewal and differentiation to …

Analyte-driven disassembly and turn-on fluorescent sensing in competitive biological media

MA Beatty, J Borges-González, NJ Sinclair… - Journal of the …, 2018 - ACS Publications
Many indicator displacement assays can detect biological analytes in water, but these often
have reduced performance in the presence of an unavoidable component: NaCl. We report …

Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role

PL Clermont, L Sun, F Crea, KL Thu, A Zhang… - British journal of …, 2014 - nature.com
Background: Polycomb group (PcG) proteins are histone modifiers known to transcriptionally
silence key tumour suppressor genes in multiple human cancers. The chromobox proteins …

Functionalized calix [4] arenes as potential therapeutic agents

MM Naseer, M Ahmed… - Chemical biology & drug …, 2017 - Wiley Online Library
Calixarenes, composed of phenolic units linked by methylene bridges at the 2, 6‐positions,
represent a versatile class of macrocyclic compounds in supramolecular chemistry that can …

Site-selective sensing of histone methylation enzyme activity via an arrayed supramolecular tandem assay

Y Liu, L Perez, AD Gill, M Mettry, L Li… - Journal of the …, 2017 - ACS Publications
Arrayed deep cavitands can be coupled to a fluorescence-based supramolecular tandem
assay that allows site-selective in situ monitoring of post-translational modifications …

Molecular recognition of Lys and Arg methylation

JE Beaver, ML Waters - ACS chemical biology, 2016 - ACS Publications
A network of reader proteins and enzymes precisely controls gene transcription through the
dynamic addition, removal, and recognition of post-translational modifications (PTMs) of …