Proteolysis targeting chimera (PROTAC) degradation of pathogenic proteins by hijacking of
the ubiquitin-proteasome-system has become a promising strategy in drug design. The …

Three families of RNA viruses, the Coronaviridae, Flaviviridae, and Filoviridae, collectively
have great potential to cause epidemic disease in human populations. The current SARS …

Dengue virus (DENV) infection causes serious health problems in humans for which no drug
is currently available. Recently, DENV NS2B-NS3 protease has been proposed as a primary …

Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are
transmitted by mosquitoes of the Aedes genus. During the last several decades, these …

Proteases from flaviviruses have gained substantial interest as potential drug targets to
combat infectious diseases caused by dengue, West Nile, Zika and related viruses. Despite …

Flaviviruses including dengue virus and Zika virus encode a unique two-component NS2B-
NS3 protease essential for maturation/infectivity, thus representing a key target for designing …

Dengue virus is an important human pathogen threating people, especially in tropical and
sub-tropical regions. The viral genome has one open reading frame and encodes one …

997 Drug repurposing approaches to fight Dengue virus infection and related diseases
Lorenzo Botta1, Mirko Rivara2, Valentina Zu Page 1 997 Drug repurposing approaches to fight …

The dengue protease NS2B/NS3pro has been reported to adopt either an 'open'or a
'closed'conformation. We have developed a conformational filter that combines NMR with …

Dengue virus infection (DVI) is a mosquito-borne disease that can lead to serious morbidity
and mortality. Dengue fever (DF) is a major public health concern that affects approximately …