Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

It is well established that different types of exercise can provide a powerful stimulus for
mitochondrial biogenesis. However, there are conflicting findings in the literature, and a …

Ageing causes loss of function in tissues and organs, is accompanied by a chronic
inflammatory process and affects life‐and healthspan. Calorie restriction (CR) is a non …

Genetic and biochemical defects of mitochondrial function are a major cause of human
disease, but their link to mitochondrial morphology in situ has not been defined. Here, we …

The plasticity of skeletal muscle can be traced down to extensive metabolic, structural and
molecular remodeling at the single fiber level. Skeletal muscle is comprised of different fiber …

Skeletal muscle aging is associated with a progressive decline in muscle mass and strength,
a process termed sarcopenia. Evidence suggests that accumulation of mitochondrial …

Background: Mitochondrial dysfunction has long been considered a major contributor to
aging and age-related diseases. Harman's Mitochondrial Free Radical Theory of Aging …

The natural aging process is carried out by a progressive loss of homeostasis leading to a
functional decline in cells and tissues. The accumulation of these changes stem from a …

Key points The maintenance of optimal mitochondrial content and function is critical for
muscle health. Mitochondrial dynamics play key roles in mitochondrial quality control; …

Muscle fatigue is defined as a decrease in maximal force or power generated in response to
contractile activity, and it is a risk factor for the development of musculoskeletal injuries. One …