1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Spirooxindoles are important synthetic targets possessing extended biological activity and
drug discovery applications. This review focuses on the various strategies for the …

Particular success has been achieved in the synthesis of new products and in processes
since the twelve principles of “green chemistry” were formulated in the 1990s. These …

Novel dispirooxindole-pyrrolidine derivatives have been synthesized through 1, 3-dipolar
cycloaddition of an azomethine ylide generated from isatin and sarcosine with the …

The first catalytic enantioselective construction of a 3, 3′-pyrrolidinyldispirooxindole
scaffold has been established via organocatalytic asymmetric 1, 3-dipolar cycloadditions of …

A green multi-component tandem strategy for metal-free synthesizing spiroacenaphthylenes
and 1H-pyrazolo [1, 2-b] phthalazine-5, 10-diones by Knoevenagel-Michael …

Spirooxindole is a compound with a unique framework and broad bioactivities in medicine.
In this study, we have reviewed various approaches or methods in synthesizing …

A sterically hindered homoenolate has been generated by the NHC‐catalyzed conjugate
umpolung of β, β‐disubstituted enals and successfully employed in a facile stereoselective …

The first catalytic asymmetric construction of a new class of bispirooxindole scaffold‐
containing tetrahydro‐β‐carboline moiety has been established through chiral phosphoric …

The catalytic asymmetric synthesis of 3, 3-disubstituted oxindoles, a big family of privileged
scaffolds in natural products and drugs, is of current interest. Recently, the catalytic …