Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly
because these injuries often respond poorly to treatment and require prolonged …

According to the minimal criteria of the International Society of Cellular Therapy,
mesenchymal stem cells (MSCs) are a population of undifferentiated cells defined by their …

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Millions of people lose or damage their organs or tissues due to disease, birth defects, or
accidents each year. Stem cells, such as embryonic stem cells (ESCs), induced pluripotent …

Mesenchymal stem cells (MSCs) are defined as cells that undergo sustained in vitro growth
and can give rise to multiple mesenchymal lineages. Because MSCs have only been …

The repair of injured tendons remains a great challenge, largely owing to a lack of in-depth
characterization of tendon cells and their precursors. We show that human and mouse …

Cell therapy involves the transplantation of human cells to replace or repair the damaged
tissues and modulate the mechanisms underlying disease initiation and progression in the …

Tendon is a specific connective tissue composed of parallel collagen fibers. The effect of this
tissue-specific matrix orientation on stem cell differentiation has not been investigated. This …

Recent advances in understanding the cellular and molecular signaling pathways and
global transcriptional regulators of adult mesenchymal stem cells have provided new …