Vascular endothelial growth factor secretion and immunosuppression are distinct potency mechanisms of human bone marrow mesenchymal stromal cells

TU Faircloth, S Temple, RN Parr, AB Tucker… - Stem Cells, 2024 - academic.oup.com
Mesenchymal stromal cells (MSCs) are investigated as cellular therapeutics for inflammatory
bowel diseases and associated perianal fistula, although consistent efficacy remains a …

Stem Cells and Stem Cell-Derived Factors for the Treatment of Inflammatory Bowel Disease with a Particular Focus on Perianal Fistulizing Disease: A Minireview on …

AL Lightner, PM Irving, GM Lord, A Betancourt - BioDrugs, 2024 - Springer
Inflammatory bowel disease remains a difficult disease to effectively treat, especially
fistulizing Crohn's disease. Perianal fistulas in the setting of Crohn's disease remain an area …

Single-cell sequencing advances in research on mesenchymal stem/stromal cells

Q Long, P Zhang, Y Ou, W Li, Q Yan, X Yuan - Human Cell, 2024 - Springer
Mesenchymal stem/stromal cells (MSCs), originating from the mesoderm, represent a
multifunctional stem cell population capable of differentiating into diverse cell types and …

Perianal Fistulizing Crohn's Disease: Outcomes of Surgical Repairs and Current State of Stem Cell-Based Therapies

AJ Dawes, AL Lightner - Clinics in Colon and Rectal Surgery, 2024 - thieme-connect.com
Perianal fistulizing Crohn's disease is one of the most disabling phenotypes of Crohn's
disease, due to the severe impairment in quality of life including social and personal …