The effect of the pineal indole hormone melatonin on the life span of mice, rats and fruit flies
has been studied using various approaches. It has been observed that in female CBA, SHR …

The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles
of environmental light. Fundamental mechanisms of how the circadian clock regulates organ …

The aim of this study was to investigate the effects of melatonin on glucose homeostasis in
young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome …

Melatonin is known to inhibit insulin secretion from rodent β‐cells through interactions with
cell‐surface MT1 and/or MT2 receptors, but the function of this hormone in human islets of …

We evaluated the effect of various light/dark regimens on the survival, life span and
tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided …

Evidences indicate that a complex relationship exists among sleep disorders, obesity and
insulin resistance. NEU-P11 is a novel melatonin agonist used in treatment of …

The results of studies on the effect of pineal indole hormone melatonin on the life span of
mice, rats, fruit flies, and worms are critically reviewed. In mice, long-term administration of …

Obesity and its associated metabolic pathologies are the most common and detrimental
diseases, affecting over 50% of the adult population. Our knowledge about the protective …

The present study aimed to investigate insulin sensitivity and GLUT4 expression protein in
pinealectomized rats, as well as to determining the effects of melatonin and calorie …

In preeclampsia and gestational diabetes, the sympathetic nerves are activated, leading to
disrupted sleep. Melatonin, which transmits information to regulate the sleep-wake rhythm …