Diagnostic biomarkers for active tuberculosis: progress and challenges

BMF Nogueira, S Krishnan… - EMBO Molecular …, 2022 - embopress.org
Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious
agent, despite being preventable and curable. Early and accurate diagnosis of active TB is …

Th1 and Th17 cells in tuberculosis: protection, pathology, and biomarkers

IV Lyadova, AV Panteleev - Mediators of inflammation, 2015 - Wiley Online Library
The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete
pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) …

Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?

RR Nathavitharana, AL Garcia-Basteiro, M Ruhwald… - …, 2022 - thelancet.com
Rapid, accurate, sputum-free tests for tuberculosis (TB) triage and confirmation are urgently
needed to close the widening diagnostic gap. We summarise key technologies and review …

Tuberculosis in children

TA Thomas - Pediatric Clinics, 2017 - pediatric.theclinics.com
Despite achieving great public health strides to control tuberculosis (TB) within the United
States, it remains an enormous public health issue worldwide. Accurate statistics on …

Update on tuberculosis biomarkers: from correlates of risk, to correlates of active disease and of cure from disease

D Goletti, MR Lee, JY Wang, N Walter… - …, 2018 - Wiley Online Library
Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …

Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response

T Adekambi, CC Ibegbu, S Cagle… - The Journal of …, 2015 - Am Soc Clin Investig
BACKGROUND. The identification and treatment of individuals with tuberculosis (TB) is a
global public health priority. Accurate diagnosis of pulmonary active TB (ATB) disease …

Screening tests for active pulmonary tuberculosis in children

B Vonasek, T Ness, Y Takwoingi… - Cochrane Database …, 2021 - cochranelibrary.com
Background Globally, children under 15 years represent approximately 12% of new
tuberculosis cases, but 16% of the estimated 1.4 million deaths. This higher share of …

Tuberculosis as a cause or comorbidity of childhood pneumonia in tuberculosis-endemic areas: a systematic review

JN Oliwa, JM Karumbi, BJ Marais, SA Madhi… - The lancet respiratory …, 2015 - thelancet.com
Pneumonia is a major cause of morbidity and mortality in infants and children worldwide,
with most cases occurring in tuberculosis-endemic settings. Studies have emphasised the …

Risk of tuberculosis reactivation in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis receiving non‐anti‐TNF‐targeted biologics

F Cantini, C Nannini, L Niccoli, L Petrone… - Mediators of …, 2017 - Wiley Online Library
Tuberculosis (TB) still represents an important issue for public health in underdeveloped
countries, but the use of antitumor necrosis factor agents (anti‐TNF) for the treatment of …

The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons

H Esmail, C Riou, E du Bruyn, RPJ Lai… - Annual review of …, 2018 - annualreviews.org
Globally, about 36.7 million people were living with HIV infection at the end of 2015. The
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …