Bioactive lipids, inflammation and chronic diseases

A Leuti, D Fazio, M Fava, A Piccoli, S Oddi… - Advanced Drug Delivery …, 2020 - Elsevier
Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Paracetamol–An old drug with new mechanisms of action

GW Przybyła, KA Szychowski… - Clinical and Experimental …, 2021 - Wiley Online Library
Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …

Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception

Y Jang, M Kim, SW Hwang - Journal of Neuroinflammation, 2020 - Springer
Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Exploring the pivotal immunomodulatory and anti‐inflammatory potentials of glycyrrhizic and glycyrrhetinic acids

SA Richard - Mediators of Inflammation, 2021 - Wiley Online Library
Licorice extract is a Chinese herbal medication most often used as a demulcent or elixir. The
extract usually consists of many components but the key ingredients are glycyrrhizic (GL) …

Prostaglandins and inflammation

E Ricciotti, GA FitzGerald - Arteriosclerosis, thrombosis, and …, 2011 - Am Heart Assoc
Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …

Glutathione transferases

JD Hayes, JU Flanagan… - Annu. Rev. Pharmacol …, 2005 - annualreviews.org
▪ Abstract This review describes the three mammalian glutathione transferase (GST)
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …

A current review of molecular mechanisms regarding osteoarthritis and pain

AS Lee, MB Ellman, D Yan, JS Kroin, BJ Cole… - Gene, 2013 - Elsevier
Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of
life and increased health costs. To understand this disease, physicians have been studying …

Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases

JY Park, MH Pillinger, SB Abramson - Clinical immunology, 2006 - Elsevier
Prostaglandin E2 (PGE2) is a principal mediator of inflammation in diseases such as
rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs) …

Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds

DJ Son, JW Lee, YH Lee, HS Song, CK Lee… - Pharmacology & …, 2007 - Elsevier
Bee venom (BV) therapy (BVT), the therapeutic application of BV, has been used in
traditional medicine to treat diseases, such as arthritis, rheumatism, pain, cancerous tumors …

Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation

AN Hata, RM Breyer - Pharmacology & therapeutics, 2004 - Elsevier
Prostaglandins are lipid-derived autacoids that modulate many physiological systems
including the CNS, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory …