The integration of nucleic acid amplification (NAA) with the CRISPR detection system has
led to significant advancements and opportunities for development in molecular diagnostics …

Abstract CRISPR/Cas and Argonaute (Ago) proteins, which target specific nucleic acid
sequences, can be applied as diagnostic tools. Despite high specificity and efficiency …

The World Health Organization's global initiative toward eliminating high-risk Human
Papillomavirus (hrHPV)-related cancers recommends DNA testing over visual inspection in …

Protein engineering faces challenges in finding optimal mutants from a massive pool of
candidate mutants. In this study, we introduce a deep-learning-based data-efficient fitness …

Pathogen detection is increasingly applied in medical diagnosis, food processing and
safety, and environmental monitoring. Rapid, sensitive, and accurate pathogen …

Background Malaria, a widespread parasitic disease caused by Plasmodium species,
remains a significant global health concern. Rapid and accurate detection, as well as …

Highly sensitive and rapid environmental surveillance is crucial due to the significant role of
various environmental media in transmitting multiple viruses. Specifically, when examining …

In the past decades, the broad selection of CRISPR-Cas systems has revolutionized
biotechnology by enabling multimodal genetic manipulation in diverse organisms. Rooted in …

Clustered regularly interspaced short palindromic repeat (CRISPR) has been gaining much
attention in the modern medical field and has been widely used for the diagnosis and …

Gene editing has the potential to solve fundamental challenges in agriculture,
biotechnology, and human health. CRISPR-based gene editors derived from microbes …