Host-directed therapies: modulating inflammation to treat tuberculosis

S Krug, S Parveen, WR Bishai - Frontiers in immunology, 2021 - frontiersin.org
Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

Nanocarriers: A successful tool to increase solubility, stability and optimise bioefficacy of natural constituents

AR Bilia, V Piazzini, L Risaliti, G Vanti… - Current Medicinal …, 2019 - ingentaconnect.com
Natural products are fascinating molecules in drug discovery for their exciting structure
variability and also for their interaction with various targets. Drugs multi-targeting effect …

[6]-Gingerol exhibits potent anti-mycobacterial and immunomodulatory activity against tuberculosis

A Bhaskar, A Kumari, M Singh, S Kumar… - International …, 2020 - Elsevier
The currently available anti-tuberculosis treatment (ATT) comprises exclusively of anti-
bacterial drugs, is very lengthy, has adverse side effects on the host and leads to the …

The advances in adjuvant therapy for tuberculosis with immunoregulatory compounds

J Mi, X Wu, J Liang - Frontiers in Microbiology, 2024 - frontiersin.org
Tuberculosis (TB) is a chronic bacterial disease, as well as a complex immune disease. The
occurrence, development, and prognosis of TB are not only related to the pathogenicity of …

Tuberculosis: The success tale of less explored dormant Mycobacterium tuberculosis

A Verma, A Ghoshal, VP Dwivedi… - Frontiers in Cellular and …, 2022 - frontiersin.org
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that predominantly affects
the alveolar macrophages in the respiratory tract. Upon infection, the activation of TLR2 and …

The war against tuberculosis: A review of natural compounds and their derivatives

M Maiolini, S Gause, J Taylor, T Steakin, G Shipp… - Molecules, 2020 - mdpi.com
Tuberculosis (TB), caused by the bacterial organism Mycobacterium tuberculosis, pose a
major threat to public health, especially in middle and low-income countries. Worldwide in …

Therapeutic potential of curcumin as an antimycobacterial agent

N Barua, AK Buragohain - Biomolecules, 2021 - mdpi.com
Curcumin is the principal curcuminoid obtained from the plant Curcuma longa and has been
extensively studied for its biological and chemical properties. Curcumin displays a vast …

Macrophage targeted polymeric curcumin nanoparticles limit intracellular survival of Mycobacterium tuberculosis through induction of autophagy and augment anti …

PK Gupta, P Jahagirdar, D Tripathi… - Frontiers in …, 2023 - frontiersin.org
Rapid emergence of antibiotic resistance in tuberculosis has left us with limited resources to
treat and manage multi drug resistant (MDR) cases of tuberculosis, prompting the …

Nanosized Drug Delivery Systems to Fight Tuberculosis

T Bourguignon, JA Godinez-Leon, R Gref - Pharmaceutics, 2023 - mdpi.com
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing
antitubercular therapies are long, complex, and have severe side effects that result in low …

Potential application of nanotechnology in the treatment, diagnosis, and prevention of schistosomiasis

A Qadeer, H Ullah, M Sohail, SZ Safi… - … in Bioengineering and …, 2022 - frontiersin.org
Schistosomiasis is one of the neglected tropical diseases that affect millions of people
worldwide. Globally, it affects economically poor countries, typically due to a lack of proper …