Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids
between the different compartments of eukaryotic cells. They act by recruiting and/or …

Due to its genetic tractability and increasing wealth of accessible data, the yeast
Saccharomyces cerevisiae is a model system of choice for the study of the genetics …

Exosomes are vesicles released from cells by fusion of multivesicular bodies (MVBs) with
the plasma membrane. This study aimed to investigate whether the phosphoinositide kinase …

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among
phospholipids in that its head group can be phosphorylated at multiple free hydroxyls …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Fungal vacuoles are acidic organelles with degradative and storage capabilities that have
many similarities to mammalian lysosomes and plant vacuoles. In the past several years …

Rab3 is a neuronal GTP-binding protein that regulates fusion of synaptic vesicles and is
essential for long-term potentiation of hippocampal mossy fibre synapses,,,,. More than thirty …

Phosphoinositide 3-kinases (PI 3-Ks) 1 are a subfamily of lipid kinases that catalyze the
addition of a phosphate molecule specifically to the 3-position of the inositol ring of …

Sorting of signal-transducing cell surface receptors within multivesicular bodies (MVBs) is
required for their rapid down-regulation and degradation within lysosomes. Yeast mutants …