Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

X Li, X Jiang, J Sun, C Zhu, X Li, L Tian… - Annals of the New …, 2017 - Wiley Online Library
Cadmium (Cd) damages the liver, kidney, bones, reproductive system, and other organs.
Flavonoids, such as anthocyanins and flavonols, which are commonly found in plant foods …

[HTML][HTML] Exposure to low-dose cadmium induces testicular ferroptosis

L Xiong, B Zhou, JL Young, K Wintergerst… - … and environmental safety, 2022 - Elsevier
As an environmental pollutant, cadmium (Cd) has been widely reported to induce male
infertility due to its gonadotoxicity. However, the specific mechanism of Cd-induced testicular …

Heavy metal exposure, oxidative stress and semen quality: exploring associations and mediation effects in reproductive-aged men

Y He, L Zou, W Luo, Z Yi, P Yang, S Yu, N Liu, J Ji… - Chemosphere, 2020 - Elsevier
Background Heavy metal exposure induces oxidative stress, which is critical for adverse
male reproductive health. Objective To explore the mediating effect of oxidative stress on the …

Melatonin modulates Nrf2 activity to protect porcine pre‐pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium

D Bartolini, I Arato, F Mancuso… - Journal of Pineal …, 2022 - Wiley Online Library
Melatonin (MLT) is a cytoprotective agent holding potential to prevent cadmium (Cd) toxicity
and its impact in testicular function and fertility. In this study, we explored such potential in …

Protective effect of naringenin against cadmium-induced testicular toxicity in male SD rats

J Wang, H Zhu, S Lin, K Wang, H Wang, Z Liu - Journal of Inorganic …, 2021 - Elsevier
This study aimed to investigate the effect of naringenin (Nar) on cadmium (Cd)-induced
testicular toxicity. Twenty-four male Sprague–Dawley (SD) rats aged 5 weeks were used …

Subacute testicular toxicity to cadmium exposure intraperitoneally and orally

VGS Mouro, ALP Martins, J Silva… - Oxidative medicine …, 2019 - Wiley Online Library
The toxic effects of cadmium (Cd) on reproductive parameters are widely described in the
literature. Experimental models often make use of the intraperitoneal route (ip), although …

Infliximab abrogates cadmium-induced testicular damage and spermiotoxicity via enhancement of steroidogenesis and suppression of inflammation and apoptosis …

R Habib, SA Wahdan, AM Gad, SS Azab - … and environmental safety, 2019 - Elsevier
Cadmium (Cd) is a serious environmental and occupational contaminant that represents a
serious health hazard to humans and other animals. Reproductive health problems have …

The Role of Ferroptosis in Environmental Pollution-Induced Male Reproductive System Toxicity

S Wu, Y Ga, D Ma, S Hou, Q Hui, Z Hao - Environmental Pollution, 2024 - Elsevier
This article provides a comprehensive review of the toxic effects of environmental pollution
on the male reproductive system, with a particular emphasis on ferroptosis, a form of …

Differential susceptibility of germ and Leydig cells to cadmium‐mediated toxicity: impact on testis structure, adiponectin levels, and steroidogenesis

MC Cupertino, RD Novaes, EC Santos… - Oxidative medicine …, 2017 - Wiley Online Library
This study investigated the relationship between germ and Leydig cell death, testosterone,
and adiponectin levels in cadmium‐mediated acute toxicity. Cadmium chloride was …

[HTML][HTML] Evidence of the protective role of D-Aspartate in counteracting/preventing cadmium-induced oxidative stress in the rat testis

M Venditti, A Santillo, D Latino, MB Rhouma… - Ecotoxicology and …, 2023 - Elsevier
Cadmium (Cd), by producing oxidative stress and acting as an endocrine disruptor, is known
to cause severe testicular injury, documented by histological and biomolecular alterations …