Drugs targeting APOE4 that regulate beta‐amyloid aggregation in the brain: therapeutic potential for Alzheimer's disease
J Poblano, I Castillo‐Tobías, L Berlanga… - Basic & Clinical …, 2024 - Wiley Online Library
Alzheimer's disease is characterized by progressive cognitive decline, and behavioural and
psychological symptoms of dementia are common. The APOE ε4 allele, a genetic risk factor …
psychological symptoms of dementia are common. The APOE ε4 allele, a genetic risk factor …
[HTML][HTML] A Bioinformatics-Based Study on Methylation Alterations of the FBLN1 Gene in Hippocampal Tissue of Alzheimer's Disease Model DKO and DTG Mice
R Tang, Y Jian, Z Hu, L Li, H Wang, P Miao… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD) is characterized by progressive cognitive decline and late-stage
neurobehavioral issues marked by amyloid-beta plaques and Tau protein tangles. This …
neurobehavioral issues marked by amyloid-beta plaques and Tau protein tangles. This …
Tackling APOE's structural challenges via in silico modeling in the era of neural networks: Can AlphaFold II help circumvent the problem of lacking full-length protein …
AA Mamchur, MV Ivanov, LR Matkava, VS Yudin… - Archives of Biochemistry …, 2024 - Elsevier
The APOE gene, encoding apolipoprotein E, is a predictor of longevity and age-related
diseases. Despite numerous genetic studies, the data on molecular mechanisms by which …
diseases. Despite numerous genetic studies, the data on molecular mechanisms by which …