Interplay between autophagy and the ubiquitin-proteasome system and its role in the pathogenesis of age-related macular degeneration

J Blasiak, E Pawlowska, J Szczepanska… - International journal of …, 2019 - mdpi.com
Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis
factors, including defective cellular waste management in retinal pigment epithelium (RPE) …

Research progress of exosomes in pathogenesis, diagnosis, and treatment of ocular diseases

X Feng, Z Peng, L Yuan, M Jin, H Hu, X Peng… - … in Bioengineering and …, 2023 - frontiersin.org
Exosomes are natural extracellular vesicles with a diameter of 30–150 nm, which exist in
biological fluids and contain biomolecules related to the parent cell, such as proteins …

Roles of exosomes in ocular diseases

J Liu, F Jiang, Y Jiang, Y Wang, Z Li, X Shi… - International journal …, 2020 - Taylor & Francis
Exosomes, nanoscale vesicles with a diameter of 30 to 150 nm, are composed of a lipid
bilayer, protein, and genetic material. Exosomes are secreted by virtually all types of cells in …

Endogenous and exogenous regulation of redox homeostasis in retinal pigment epithelium cells: An updated antioxidant perspective

Y Markitantova, V Simirskii - International Journal of Molecular Sciences, 2023 - mdpi.com
The retinal pigment epithelium (RPE) performs a range of necessary functions within the
neural layers of the retina and helps ensure vision. The regulation of pro-oxidative and …

[HTML][HTML] Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers

N Shah, M Ishii, C Brandon, Z Ablonczy, J Cai… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Retinal pigment epithelium (RPE) alterations in age-related macular degeneration occur in
patches, potentially involving long-distance communication between damaged and healthy …

IGF-1, inflammation and retinal degeneration: a close network

AI Arroba, A Campos-Caro… - Frontiers in aging …, 2018 - frontiersin.org
Retinal degenerative diseases are a group of heterogeneous diseases that include age-
related macular degeneration (AMD), retinitis pigmentosa (RP), and diabetic retinopathy …

Exosomal non-coding RNAs in angiogenesis: Functions, mechanisms and potential clinical applications

Z Wang, W Tan, B Li, J Zou, Y Li, Y Xiao, Y He… - Heliyon, 2023 - cell.com
Exosomes are extracellular vesicles that can be produced by most cells. Exosomes act as
important intermediaries in intercellular communication, and participate in a variety of …

Vitreous humor proteome: unraveling the molecular mechanisms underlying proliferative and neovascular vitreoretinal diseases

FM Dos Santos, S Ciordia, J Mesquita… - Cellular and Molecular …, 2023 - Springer
Proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and
neovascular age-related macular degeneration (nAMD) are among the leading causes of …

Salivary exosomes in health and disease: future prospects in the eye

A Liu, B Hefley, P Escandon, SE Nicholas… - International journal of …, 2023 - mdpi.com
Exosomes are a group of vesicles that package and transport DNA, RNA, proteins, and
lipids to recipient cells. They can be derived from blood, saliva, urine, and/or other biological …

Extracellular vesicles: an emerging player in retinal homeostasis

A Chatterjee, R Singh - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Extracellular vesicles (EVs) encompass secreted membrane vesicles of varied sizes,
including exosomes (− 30–200 nm) and microvesicles (MVs) that are∼ 100–1,000 nm in …