Many past and recent advances in the field of iron metabolism have relied upon the
discovery of divalent metal transporter 1, DMT1 in 1997. DMT1 is the major iron transporter …

The Hippo signaling pathway was initially defined by genetic studies in Drosophila to
regulate tissue growth and organ size [1, 2]. This pathway is highly conserved in mammals …

Inactivation of ARID1A and other components of the nuclear SWI/SNF protein complex
occurs at very high frequencies in a variety of human malignancies, suggesting a …

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional
addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately …

Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the
TEAD transcription factor, and plays a critical role in organ size regulation. YAP is …

Ubiquitin-mediated proteolysis regulates the activity of diverse receptor systems. Here, we
identify Smurf2, a C2-WW-HECT domain ubiquitin ligase and show that Smurf2 associates …

ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

The highly conserved and ubiquitously expressed 14‐3‐3 proteins regulate differentiation,
cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in …

THE NIMA kinase is essential for progression through mitosis in Aspergillus nidulans 1–6,
and there is evidence for a similar pathway in other eukaryotic cells5–8. Here we describe …

In mammals, skin begins as a single-layered epithelium, which, through a series of signals,
either stratifies and differentiates to become epidermis or invaginates downward to make …