High‐dose methotrexate (HDMTX) is active against various malignancies; it possesses
serious toxicities and is associated with patient characteristics, dosage regimens …

Despite significant advancements in oncology, conventional chemotherapy remains the
primary treatment for diverse malignancies. Acute kidney injury (AKI) stands out as one of …

High-dose methotrexate (HD-MTX) therapy is widely used in patients with acute
lymphoblastic leukemia (ALL) and lymphoma. However, some patients experience delayed …

Background High‐dose (HD) methotrexate (MTX) is an essential component of treatment
protocols in acute lymphoblastic leukemia, aggressive lymphoma, and osteosarcoma …

Purpose Intravenous (IV) sodium bicarbonate is typically used in alkalization regimens for
the safe use of the chemotherapeutic agent high-dose methotrexate (HDMTX). Urine …

Abstract What is Known and Objective Methotrexate (MTX) is an antimetabolic antitumor
drug with high individual differences and may lead to severe toxicities in a considerable …

Abstract Study Objective To develop and validate a model for predicting acute kidney injury
(AKI) after high‐dose methotrexate (HDMTX) exposure. Design Retrospective analysis …

Purpose Urinary alkalinization with intravenous sodium bicarbonate is standard during high-
dose methotrexate administration. Due to a national intravenous sodium bicarbonate …

Background Glucarpidase is indicated for treating delayed methotrexate (MTX) elimination
due to impaired renal function. Although glucarpidase is capable of rapidly eliminating MTX …

Purpose High dose methotrexate (HDMTX) acute kidney injury (AKI) results in prolonged
hospitalization and treatment delays. Using a pharmacologically-based approach, HDMTX …