[HTML][HTML] Molecular genetics of early-onset colorectal cancer

O Marx, M Mankarious, G Yochum - World Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Early-onset colorectal cancer (EOCRC) has been rising in global prevalence and incidence
over the past several decades. Environmental influences, including generational lifestyle …

LncRNA NALT1 promotes colorectal cancer progression via targeting PEG10 by sponging microRNA-574-5p

M Ye, L Zhao, L Zhang, S Wu, Z Li, Y Qin, F Lin… - Cell death & …, 2022 - nature.com
Colorectal cancer (CRC) is currently one of the commonest tumors and the main reason for
cancer-related deaths worldwide. It has been reported that long non-coding RNAs …

Reduced expression of alanyl aminopeptidase is a robust biomarker of non‐familial adenomatous polyposis and non‐hereditary nonpolyposis colorectal cancer …

YJ Ha, YJ Shin, KH Tak, JL Park, JH Kim… - Cancer …, 2023 - Wiley Online Library
Background Early‐onset colorectal cancer (EOCRC) has been increasing in incidence
worldwide but its genomic pathogenesis is mostly undetermined. This study aimed to identify …

[HTML][HTML] A distinct innate immune signature of early onset colorectal cancer

IH Gardner, R Siddharthan, K Watson, E Dewey… - …, 2021 - journals.aai.org
Despite a decrease in the prevalence of colorectal cancer (CRC) over the last 40 y, the
prevalence of CRC in people under 50 y old is increasing around the globe. Early onset (≤ …

Survival stratification for colorectal cancer via multi-omics integration using an autoencoder-based model

H Song, C Ruan, Y Xu, T Xu, R Fan… - Experimental …, 2022 - journals.sagepub.com
Prognosis stratification in colorectal cancer helps to address cancer heterogeneity and
contributes to the improvement of tailored treatments for colorectal cancer patients. In this …

Precise Therapy Using the Selective Endogenous Encapsidation for Cellular Delivery Vector System

V Tatarūnas, I Čiapienė, A Giedraitienė - Pharmaceutics, 2024 - mdpi.com
Interindividual variability in drug response is a major problem in the prescription of
pharmacological treatments. The therapeutic effect of drugs can be influenced by human …

Identification of differentially expressed genes and splicing events in early-onset colorectal cancer

OM Marx, MM Mankarious, WA Koltun… - Frontiers in …, 2024 - frontiersin.org
The incidence of colorectal cancer (CRC) has been steadily increasing in younger
individuals over the past several decades for reasons that are incompletely defined …

[HTML][HTML] Novel DNA methylation-based epigenetic signatures in colorectal cancer from peripheral blood leukocytes

SY Jung, H Yu, X Tan, M Pellegrini - American Journal of Cancer …, 2024 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a multifactorial disease characterized by accumulation of
multiple genetic and epigenetic alterations, transforming colonic epithelial cells into …

Structural evidence that MOAP1 and PEG10 are derived from retrovirus/retrotransposon Gag proteins

K Zurowska, A Alam… - Proteins: Structure …, 2022 - Wiley Online Library
The Gag proteins of retroviruses play an essential role in virus particle assembly by forming
a protein shell or capsid and thus generating the virion compartment. A variety of human …

The potential of cancer stem cells for personalized risk assessment and therapeutic intervention in individuals with intrahepatic cholangiocarcinoma

J Zhang, T Cui, J Xu, P Wang, C Lv, G Pan - Discover Oncology, 2024 - Springer
Background Accumulating evidence suggests that intrahepatic cholangiocarcinoma (ICC) is
a stem cell-based disease, but information on the biology of cancer stem cells (CSC) in ICC …