Life and death of circulating cell-free DNA

A Kustanovich, R Schwartz, T Peretz… - Cancer biology & …, 2019 - Taylor & Francis
Tumor-specific, circulating cell-free DNA in liquid biopsies is a promising source of
biomarkers for minimally invasive serial monitoring of treatment responses in cancer …

Liquid biopsies: donor-derived cell-free DNA for the detection of kidney allograft injury

M Oellerich, K Sherwood, P Keown, E Schütz… - Nature Reviews …, 2021 - nature.com
In kidney transplantation, the use of minimally invasive damage biomarkers that are more
sensitive and specific than plasma creatinine will be crucial to enable early, actionable …

WITHDRAWN: Executive Summary-The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients

A Velleca, MA Shullo, K Dhital, E Azeka, M Colvin… - 2022 - Elsevier
WITHDRAWN: Executive Summary - The International Society for Heart and Lung
Transplantation (ISHLT) guidelines for the care of heart transplant recipients - ScienceDirect Skip …

Donor-specific cell-free DNA as a biomarker in solid organ transplantation. A systematic review

SR Knight, A Thorne, MLL Faro - Transplantation, 2019 - journals.lww.com
Background There is increasing interest in the use of noninvasive biomarkers to reduce the
risks posed by invasive biopsy for monitoring of solid organ transplants (SOTs). One such …

The trifecta study: comparing plasma levels of donor-derived cell-free DNA with the molecular phenotype of kidney transplant biopsies

PF Halloran, J Reeve, KS Madill-Thomsen… - Journal of the …, 2022 - journals.lww.com
Background The relationship between the donor-derived cell-free DNA fraction (dd-cfDNA
[%]) in plasma in kidney transplant recipients at time of indication biopsy and gene …

Clinical validation of a next-generation sequencing-based multi-cancer early detection “liquid biopsy” blood test in over 1,000 dogs using an independent testing set …

A Flory, KM Kruglyak, JA Tynan, LM McLennan… - PLoS …, 2022 - journals.plos.org
Cancer is the leading cause of death in dogs, yet there are no established screening
paradigms for early detection. Liquid biopsy methods that interrogate cancer-derived …

Donor-derived cell-free DNA as a diagnostic tool in transplantation

M Oellerich, K Budde, B Osmanodja… - Frontiers in …, 2022 - frontiersin.org
There is a need to improve personalized immunosuppression in organ transplantation to
reduce premature graft loss. Biomarkers are needed to better detect rejection, asymptomatic …

Liquid Biopsy Based on Cell-Free DNA and RNA

C Loy, L Ahmann, I De Vlaminck… - Annual Review of …, 2024 - annualreviews.org
This review delves into the rapidly evolving landscape of liquid biopsy technologies based
on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in …

New perspectives on the importance of cell-free DNA biology

AJ Bronkhorst, V Ungerer, A Oberhofer, S Gabriel… - Diagnostics, 2022 - mdpi.com
Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

Signed in blood: circulating tumor DNA in cancer diagnosis, treatment and screening

JJ Adashek, F Janku, R Kurzrock - Cancers, 2021 - mdpi.com
Simple Summary An important advance in the diagnostic and surveillance toolbox for
oncologists is circulating tumor DNA (ctDNA). This technology can detect microscopic levels …