A review of the epithelial and stromal effects of corneal collagen crosslinking

S Bradford, S Luo, D Brown, T Juhasz, J Jester - The ocular surface, 2023 - Elsevier
Induced corneal collagen crosslinking and mechanical stiffening via ultraviolet-A
photoactivation of riboflavin (UVA CXL) is now a common treatment for corneal ectasia and …

Femtosecond lasers in cornea & refractive surgery

K Sioufi, L Zheleznyak, S MacRae, KM Rocha - Experimental Eye …, 2021 - Elsevier
Since the introduction of femtosecond laser (FS) systems for corneal flap creation in laser-
assisted in-situ keratomileusis there have been numerous applications for FS laser in …

Imaging with a twist: Three-dimensional insights of the chiral nematic phase of cellulose nanocrystals via SHG microscopy

T Legat, V Grachev, D Kabus, MP Lettinga, K Clays… - Science …, 2024 - science.org
Cellulose nanocrystals (CNCs) are bio-based nanoparticles that, under the right conditions,
self-align into chiral nematic liquid crystals with a helical pitch. In this work, we exploit the …

Morpho-mechanics of human collagen superstructures revealed by all-optical correlative micro-spectroscopies

R Mercatelli, S Mattana, L Capozzoli, F Ratto… - Communications …, 2019 - nature.com
In every biological tissue, morphological and topological properties strongly affect its
mechanical features and behaviour, so that ultrastructure, composition and mechanical …

An early finding of keratoconus: increase in corneal densitometry

M Koc, K Tekin, MI Tekin, MM Uzel, P Kosekahya… - Cornea, 2018 - journals.lww.com
Purpose: To investigate the corneal densitometry in subclinical keratoconus with normal
elevation and pachymetric parameters. Methods: Patients with clinical keratoconus in one …

In vivo two-photon microscopy of the human eye

FJ Ávila, A Gambín, P Artal, JM Bueno - Scientific reports, 2019 - nature.com
Abstract Two-photon (2P) microscopy is a powerful tool for imaging and exploring label-free
biological tissues at high resolution. Although this type of microscopy has been …

Polarized light microscopy for 3‐dimensional mapping of collagen fiber architecture in ocular tissues

B Yang, NJ Jan, B Brazile, A Voorhees… - Journal of …, 2018 - Wiley Online Library
Collagen fibers play a central role in normal eye mechanics and pathology. In ocular tissues,
collagen fibers exhibit a complex 3‐dimensional (3D) fiber orientation, with both in‐plane …

Quantitative structural imaging of keratoconic corneas using polarization-resolved SHG microscopy

C Raoux, M Schmeltz, M Bied, M Alnawaiseh… - Biomedical optics …, 2021 - opg.optica.org
The human cornea is mainly composed of collagen fibrils aligned together within stacked
lamellae. This lamellar structure can be affected in pathologies such as keratoconus, which …

Collagen ultrastructural symmetry and its malignant alterations in human breast cancer revealed by polarization‐resolved second‐harmonic generation microscopy

R Mercatelli, T Triulzi, FS Pavone… - Journal of …, 2020 - Wiley Online Library
Several specific alterations of the extracellular matrix can be considered a distinctive
hallmark of cancer. In particular, a different morphology of the collagen scaffold is frequently …

Improved quantification of collagen anisotropy with polarization‐resolved second harmonic generation microscopy

R Hristu, SG Stanciu, DE Tranca… - Journal of …, 2017 - Wiley Online Library
Imaging tissue samples by polarization‐resolved second harmonic generation microscopy
provides both qualitative and quantitative insights into collagen organization in a label‐free …