Muscle and neuronal nicotinic acetylcholine receptors: structure, function and pathogenicity

D Kalamida, K Poulas, V Avramopoulou… - The FEBS …, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …

Neuronal nicotinic receptors: from structure to function

S Leonard, D Bertrand - Nicotine & Tobacco Research, 2001 - academic.oup.com
Molecular identification of the genes and resulting protein sequences for a large number of
nicotinic acetylcholine receptor (nAChR) subunits has stimulated numerous studies …

Association of promoter variants in the α7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia

S Leonard, J Gault, J Hopkins, J Logel… - Archives of general …, 2002 - jamanetwork.com
Background The α7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) has
been implicated as a candidate gene for schizophrenia, and for an auditory sensory …

Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula

S Frahm, MA Ślimak, L Ferrarese, J Santos-Torres… - Neuron, 2011 - cell.com
Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-
CHRNA3-CHRNA5 gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor …

Bioinformatically detectable group of novel regulatory genes and uses thereof

I Bentwich - US Patent 7,250,496, 2007 - Google Patents
The present invention relates to a first group of novel genes, here identified as “genomic
address messenger” or “GAM” genes, and a second group of novel operon-like genes, here …

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

JC Wang, R Grucza, C Cruchaga, AL Hinrichs… - Molecular …, 2009 - nature.com
Alcohol dependence frequently co-occurs with cigarette smoking, another common addictive
behavior. Evidence from genetic studies demonstrates that alcohol dependence and …

Protective effect of Nigella sativa oil against acetamiprid induced reproductive toxicity in male rats

R Mosbah, Z Djerrou, A Mantovani - Drug and chemical toxicology, 2018 - Taylor & Francis
The present study was designed to investigate the adverse reproductive effects of
acetamiprid, besides the possible protective role of Nigella sativa oil (NSO), as a potential …

Nicotine and nicotinic receptors; relevance to Parkinson's disease

M Quik, JM Kulak - Neurotoxicology, 2002 - Elsevier
The development of nicotinic agonists for therapy in neurodegenerative disorders such as
Parkinson's disease is an area currently receiving considerable attention. The rationale for …

The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer

MRD Improgo, MD Scofield, AR Tapper… - Progress in …, 2010 - Elsevier
More than 1 billion people around the world smoke, with 10 million cigarettes sold every
minute. Cigarettes contain thousands of harmful chemicals including the psychoactive …

The CHRNA5–A3–B4 gene cluster in nicotine addiction

WH Berrettini, GA Doyle - Molecular psychiatry, 2012 - nature.com
Nicotine addiction (NA) is a common and devastating disease, such that the annual number
of deaths (world-wide) from tobacco-related diseases will double from 5 million in the year …