Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …

Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

Ferroptosis, a form of regulated necrosis driven by iron-dependent peroxidation of
phospholipids, is regulated by cellular metabolism, redox homeostasis, and various …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Altered lipid metabolism is among the most prominent metabolic alterations in cancer.
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …